Browsing by Author "Spasovski, G"
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- Bone Biopsy Practice Patterns Across Europe: the European Renal Osteodystrophy Initiative - a Position PaperPublication . Evenepoel, P; D'Haese, P; Bacchetta, J; Cannata-Andia, J; Ferreira, A; Haarhaus, M; Mazzaferro, S; Lafage Proust, MH; Salam, S; Spasovski, G; Cozzolino, MRenal osteodystrophy (ROD) is a heterogeneous group of metabolic bone diseases complicating progressive chronic kidney disease (CKD). Bone biomarkers and bone imaging techniques may help to assess bone health and predict fractures in CKD but do have important inherent limitations. By informing on bone turnover and mineralization, a bone biopsy may help to guide prevention and treatment of ROD and its consequences. According to a recent survey conducted among European nephrologists, bone biopsies are performed rather exceptionally, both for clinical and research purposes. Obviously, clinical research in the field of ROD is threatened by vanishing clinical and pathological expertise, small patient cohorts and scientific isolation. In March 2016, the European Renal Osteodystrophy (EU-ROD) initiative was created under the umbrella of the ERA-EDTA CKD-mineral and bone disorder (MBD) Working Group to revitalize bone biopsy as a clinically useful tool in the diagnostic workup of CKD-MBD and to foster research on the epidemiology, implications and reversibility of ROD. As such, the EU-ROD initiative aims to increase the understanding of ROD and ultimately to improve outcomes in CKD patients.
- Cognitive Disorders in Patients with Chronic Kidney Disease: Approaches to Prevention and TreatmentPublication . Pépin, M; Klimkowicz‐Mrowiec, A; Godefroy, O; Delgado, P; Carriazo, S; Ferreira, AC; Golenia, A; Malyszko, J; Grodzicki, T; Giannakou, K; Paolisso, G; Barbieri, M; Garneata, L; Mocanu, CA; Liabeuf, S; Spasovski, G; Zoccali, C; Bruchfeld, A; Farinha, A; Arici, M; Capasso, G; Wiecek, A; Massy, ZABackground: Cognitive impairment is common in patients with chronic kidney disease (CKD), and early intervention may prevent the progression of this condition. Methods: Here, we review interventions for the complications of CKD (anemia, secondary hyperparathyroidism, metabolic acidosis, harmful effects of dialysis, the accumulation of uremic toxins) and for prevention of vascular events, interventions that may potentially be protective against cognitive impairment. Furthermore, we discuss nonpharmacological and pharmacological methods to prevent cognitive impairment and/or minimize the latter's impact on CKD patients' daily lives. Results: A particular attention on kidney function assessment is suggested during work-up for cognitive impairment. Different approaches are promising to reduce cognitive burden in patients with CKD but the availabe dedicated data are scarce. Conclusions: There is a need for studies assessing the effect of interventions on the cognitive function of patients with CKD.