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Recent Developments in Biologic Therapies for the Treatment of Patients with Systemic Lupus Erythematosus

dc.contributor.authorCarreira, P
dc.contributor.authorIsenberg, D
dc.date.accessioned2021-11-22T15:30:42Z
dc.date.available2021-11-22T15:30:42Z
dc.date.issued2019
dc.description.abstractSLE has a complex pathogenesis, and multiple therapeutic targets have been discovered in recent years. In spite of belimumab being approved by the US Food and Drug Administration and the widespread use of rituximab, there have been many failed attempts to treat SLE successfully using biologic agents. In this review, we consider newer biologic approaches that might offer the hope of improving the outcome of SLE patients. These include the fully humanized anti-CD20 mAbs, PEGylated anti-CD40L, IFNα inhibitors, rigerimod and immune complexes blockade.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRheumatology (Oxford). 2019 Mar 1;58(3):382-387.pt_PT
dc.identifier.doi10.1093/rheumatology/key064.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3913
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Presspt_PT
dc.subjectHCC DAUTOIMpt_PT
dc.subjectAntibodies, Monoclonal, Humanized / therapeutic usept_PT
dc.subjectBiological Products / therapeutic use*pt_PT
dc.subjectHumanspt_PT
dc.subjectImmunoglobulin Fab Fragments / therapeutic usept_PT
dc.subjectImmunologic Factors / therapeutic use*pt_PT
dc.subjectInterferon-alpha / therapeutic usept_PT
dc.subjectLupus Erythematosus, Systemic / drug therapy*pt_PT
dc.subjectPolyethylene Glycols / therapeutic usept_PT
dc.subjectRituximab / therapeutic usept_PT
dc.subjectTreatment Outcomept_PT
dc.titleRecent Developments in Biologic Therapies for the Treatment of Patients with Systemic Lupus Erythematosuspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage387pt_PT
oaire.citation.startPage382pt_PT
oaire.citation.titleRheumatologypt_PT
oaire.citation.volume58pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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