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Resumo(s)
Cerebral venous thrombosis (CVT) accounts for 0.5-1% of all strokes and 24-50% of these patients develop acute symptomatic seizures (AS). Clinical and radiological characteristics have been associated with an increased risk of AS in CVT. We aimed to identify clinical and imaging predictors associated with a higher risk of AS in CVT patients.We conducted a single-centre, retrospective cohort study and included all patients with CVT admitted to our stroke unit between January/2011-December/2022. Our primary outcome was AS occurence. Clinical and radiological characteristics were compared through a logistic binary regression, followed by a multivariable analysis.We included 156 patients, 80.8% female and a mean age of 41.5 ± 15.2 years. Fifty-two patients (33.3%) had a seizure during follow-up, the majority as AS (30.1%). We found an increased risk of AS in patients with focal signs at presentation (OR 5.35), superior longitudinal sinus (SLS) or cortical vein involvement (OR 5.03; OR 3.94), hemorrhagic lesions or oedema (OR 3.88; OR 4.17) and lesions located in the frontal or the parietal lobe (OR 4.61; OR 4.61). A multivariable analysis was also conducted and only SLS involvement (OR 6.06), cortical vein involvement (OR 2.76) and hemorrhagic lesion (OR 3.47) remained statistically significant.Seizures occurred in about a third of our CVT patients, the majority as AS. Haemorrhagic lesions, SLS and cortical vein involvement had a stronger association with AS that may raise our awareness for the risk of seizures in this population during the acute phase.
Descrição
Palavras-chave
HSJ NEU HSJ UCV Adult Female Male Humans Middle Aged Cerebral Veins / diagnostic imaging Intracranial Thrombosis* / complications Intracranial Thrombosis* / diagnostic imaging Intracranial Thrombosis* / epidemiology Retrospective Studies Seizures* / diagnosis Seizures* / epidemiology Seizures* / diagnostic imaging Seizures* / etiology Venous Thrombosis* / complications Venous Thrombosis* / diagnostic imaging Venous Thrombosis* / epidemiology
Contexto Educativo
Citação
Neurol Sci . 2025 Sep;46(9):4493-4496. doi: 10.1007/s10072-025-08256-x.
Editora
Springer