Rego de Figueiredo, IGuerreiro Castro, SBernardino, VSilva Nunes, JAlves, PMoraes-Fontes, MF2018-10-222018-10-222018Neuromuscul Disord. 2018 Sep;28(9):791-797http://hdl.handle.net/10400.17/3086We present a case report of a 42 year old female, diagnosed at the age of 3 with Juvenile Dermatomyositis. The clinical course was severe and refractory to immunosuppressive therapy. Currently, she is mostly affected by severe muscle atrophy, large joint contractures, calcinosis, and a lipodystrophy associated metabolic syndrome with hypertriglyceridemia, insulin resistance, high total testosterone and hepatic steatosis. She developed Hodgkin´s lymphoma in the course of her disease. Personalized therapeutic choices are discussed as regards juvenile dermatomyositis complications.engCalcinosis/diagnosisCalcinosis/pathologyDermatomyositis/diagnosisDermatomyositis/pathologyHCC DAUTOIMHDE IMAHCC ENDDisease ProgressionInsulin ResistanceLipodystrophy/diagnosisLipodystrophy/pathologyMetabolic Syndrome/diagnosisMetabolic Syndrome/pathologyMuscular Atrophy/diagnosisMuscular Atrophy/pathologySeverity of Illness Indexjournal article10.1016/j.nmd.2018.06.011