Cristóvão Marques, JBarata, RLemos Garcia, JNavarro, DGóis, MSousa, HCotovio, PRibeiro, FNolasco, F2023-01-262023-01-262021Clin Nephrol Ren Care 2021, 7:065http://hdl.handle.net/10400.17/4360Extraintestinal manifestations of inflammatory bowel disease are common and extendable to all organs. Kidney and lower genitourinary system occurs in 4-23% of cases. This may be dependent on inflammatory bowel disease activity, secondary to metabolic disorders, drugs or others. We present a case of a 68-year-old man with ulcerative colitis for 22 years admitted in our department for acute nephritic syndrome. Urinary microscopy suggested glomerular injury. A kidney biopsy was performed and was compatible with acute interstitial nephritis and IgA nephropathy. Toxicity of mesalazine and glomerulonephritis secondary to ulcerative colitis were assumed. The patient suspended mesalazine and started prednisolone with clinical improvement. Our purpose is to sensitize the importance of having a prompt and thorough evaluation of acute kidney injury in patients with inflammatory bowel disease. We briefly review the broad spectrum of kidney manifestations in this population, focusing on mesalazine-induced nephrotoxicity.engInflammatory bowel diseasekidney injury/acuteIgA nephropathyTubulointerstitial nephritisMesalazineHCC PAT CLINHCC NEFjournal article