Cardoso, FSMarcelino, PBagulho, LKarvellas, C2017-11-132017-11-132017-06J Crit Care. 2017 Jun;39:25-30http://hdl.handle.net/10400.17/2791Acute liver failure is a rare but potentially devastating disease. Throughout the last few decades, acute liver failure outcomes have been improving in the context of the optimized overall management. This positive trend has been associated with the earlier recognition of this condition, the improvement of the intensive care unit management, and the developments in emergent liver transplantation. Accordingly, we aimed to review the current diagnostic and therapeutic approach to this syndrome, especially in the intensive care unit setting.engHCC UCICritical Care/trendsIntensive Care UnitsLiver Failure, Acute/therapyLiver TransplantationReferral and Consultationjournal article10.1016/j.jcrc.2017.01.003