Cabete, JLestre, SCampos, S2015-02-162015-02-162015An Bras Dermatol. 2015 Jan-Feb;90(1):120-2http://hdl.handle.net/10400.17/2005Photodynamic therapy has been described as an effective therapeutic option in selected cases of anogenital lichen sclerosus that are refractory to first-line treatments. However, procedure-related pain is a limiting factor in patient adherence to treatment. The authors report the case of a 75-year-old woman with highly symptomatic vulvar lichen sclerosus, successfully treated with photodynamic therapy. An inhaled 50% nitrous oxide/oxygen premix was administered during sessions, producing a pain-relieving, anxiolytic, and sedative effect without loss of consciousness. This ready-to-use gas mixture may be a well-tolerated and accepted alternative to classical anesthetics in Photodynamic therapy, facilitating patients' adherence to illumination of pain-prone areas.engHSAC DERAnesthetics, Inhalation/administration & dosageConscious SedationNitrous Oxide/administration & dosageOxygen/administration & dosagePhotochemotherapy/methodsReproducibility of ResultsTime FactorsTreatment OutcomeVulvar Lichen Sclerosus/drug therapyjournal article