Barreiros Mota, IMarques, CFaria, CNeto, MTCordeiro-Ferreira, GVirella, DPita, APereira-da-Silva, LCalhau, C2020-05-222020-05-222019BMJ Open . 2019 Nov 24;9(11):e028916http://hdl.handle.net/10400.17/3453The gut microbiota plays a main role in the maintenance of host's health. Exposure to different conditions in early life contributes to distinct 'pioneer' bacterial communities in the intestine, which shape the newborn infant development. Newborn infants with congenital malformations of the gastrointestinal tract (CMGIT), necrotising enterocolitis (NEC) and spontaneous intestinal perforation (SIP) commonly require abdominal surgery and enterostomy. The knowledge about the colonisation of these newborns' intestine by microorganisms is scarce. This protocol is designed to explore the microbial colonisation over time of the proximal intestinal remnant in newborn infants who underwent surgery for CMGIT, NEC or SIP and require enterostomy.engCongenital MalformationsDysbiosisEnterostomyMicrobiotaNecrotizing EnterocolitisInfant, NewbornHDE CINVHDE UCI NEOjournal article10.1136/bmjopen-2019-028916