Amaral, RJácome, CAlmeida, RPereira, AMAlves-Correia, MMendes, SRodrigues, JCCarvalho, JAraújo, LCosta, ASilva, ATeixeira, MFFerreira-Magalhães, MAlves, RRMoreira, ASFernandes, RMFerreira, RLeiria-Pinto, PNeuparth, NBordalo, DTodo Bom, ACálix, MJFerreira, TGomes, JVidal, CMendes, AVasconcelos, MJSilva, PMFerraz, JMorête, APinto, CSSantos, NLoureiro, CCArrobas, AMarques, MLLozoya, CLopes, CCardia, FLoureiro, CCCâmara, RVieira, ISilva, SSilva, ERodrigues, NFonseca, JA2021-06-242021-06-242021Int J Environ Res Public Health. 2021;18(3):1015http://hdl.handle.net/10400.17/3752We aimed to identify persistent asthma phenotypes among adolescents and to evaluate longitudinally asthma-related outcomes across phenotypes. Adolescents (13-17 years) from the prospective, observational, and multicenter INSPIRERS studies, conducted in Portugal and Spain, were included (n = 162). Latent class analysis was applied to demographic, environmental, and clinical variables, collected at a baseline medical visit. Longitudinal differences in clinical variables were assessed at a 4-month follow-up telephone contact (n = 128). Three classes/phenotypes of persistent asthma were identified. Adolescents in class 1 (n = 87) were highly symptomatic at baseline and presented the highest number of unscheduled healthcare visits per month and exacerbations per month, both at baseline and follow-up. Class 2 (n = 32) was characterized by female predominance, more frequent obesity, and uncontrolled upper/lower airways symptoms at baseline. At follow-up, there was a significant increase in the proportion of controlled lower airway symptoms (p < 0.001). Class 3 (n = 43) included mostly males with controlled lower airways symptoms; at follow-up, while keeping symptom control, there was a significant increase in exacerbations/month (p = 0.015). We have identified distinct phenotypes of persistent asthma in adolescents with different patterns in longitudinal asthma-related outcomes, supporting the importance of profiling asthma phenotypes in predicting disease outcomes that might inform targeted interventions and reduce future risk.engAdolescentFemaleHumansMalePhenotypePortugalProspective StudiesSpainAsthmaHDE ALERjournal article10.3390/ijerph18031015