Cristo, FInácio, JMAlmeida, SMendes, PMartins, DSMaio, JAnjos, RBelo, JA2018-02-152018-02-152017BMC Med Genet. 2017 Jul 24;18(1):77http://hdl.handle.net/10400.17/2895Perturbations on the Left-Right axis establishment lead to laterality defects, with frequently associated Congenital Heart Diseases (CHDs). Indeed, in the last decade, it has been reported that the etiology of isolated cases of CHDs or cases of laterality defects with associated CHDs is linked with variants of genes involved in the Nodal signaling pathway.engFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHeart Defects, CongenitalHeart Septal Defects, VentricularHumansIntercellular Signaling Peptides and ProteinsMaleMutationNodal ProteinPhenotypePolymorphism, Single NucleotideSignal TransductionHDE GENjournal article10.1186/s12881-017-0444-1