Ayoub, CKritharides, LYam, YChen, LHossain, AAchenbach, SAl-Mallah, MAndreini, DBerman, DBudoff, MCademartiri, FCallister, TChang, HJChinnaiyan, KCury, RDelago, ADunning, AFeuchtner, GGomez, MGransar, HHadamitzky, MHausleiter, JHindoyan, NKaufmann, PKim, YJLeipsic, JMaffei, EMarques, HPontone, GRaff, GRubinshtein, RShaw, LVillines, TMin, JChow, B2019-11-262019-11-262018-11Heart Vessels. 2018 Nov;33(11):1288-1300.http://hdl.handle.net/10400.17/3367Extent of coronary atherosclerotic disease (CAD) burden on coronary computed tomography angiography (CCTA) as measured by segment involvement score (SIS) has a prognostic value. We sought to investigate the incremental prognostic value of 'age adjusted SIS' (aSIS), which may be a marker of premature atherosclerosis and vascular age. Consecutive patients were prospectively enrolled into the CONFIRM (Coronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicentre) multinational observational study. Patients were followed for the outcome of all-cause death. aSIS was calculated on CCTA for each patient, and its incremental prognostic value was evaluated. A total of 22,211 patients [mean age 58.5 ± 12.7 years, 55.8% male) with a median follow-up of 27.3 months (IQR 17.8, 35.4)] were identified. After adjustment for clinical factors and presence of obstructive CAD, higher aSIS was associated with increased death on multivariable analysis, with hazard ratio (HR) 2.40 (1.83-3.16, p < 0.001), C-statistic 0.723 (0.700-0.756), net reclassification improvement (NRI) 0.36 (0.26-0.47, p < 0.001), and relative integrated discrimination improvement (IDI) 0.33 (p = 0.009). aSIS had HR 3.48 (2.33-5.18, p < 0.001) for mortality in those without obstructive CAD, compared to HR 1.79 (1.25-2.58, p = 0.02) in those with obstructive CAD. In conclusion, aSIS has an incremental prognostic value to traditional risk factors and obstructive CAD, and may enhance CCTA risk stratification.engAge FactorsAgedAgingComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary VesselsFemaleFollow-Up StudiesHumansMaleMiddle AgedPlaque, AtheroscleroticPredictive Value of TestsPrognosisProspective StudiesRisk FactorsTime FactorsRegistriesHCC CIRjournal article10.1007/s00380-018-1188-3