Arcângelo, JGuerra-Pinto, FPinto, AGrenho, ANavarro, AMartin Oliva, X2021-09-072021-09-072019Foot Ankle Surg. 2019 Apr;25(2):96-105.http://hdl.handle.net/10400.17/3838Background: Periprosthetic cystic osteolysis is a well-known complication of total ankle replacement. Several theories have been proposed for its aetiology, based on individual biomechanical, radiological, histopathology and outcome studies. Methods: Studies that met predefined inclusion/exclusion criteria were analysed to identify literature describing the presence of peri-prosthetic ankle cystic osteolysis. Quantitative data from the selected articles were combined and statistically tested in order to analyse possible relations between ankle peri-prosthetic bone cysts and specific implant characteristics. Results: Twenty-one articles were elected, totalizing 2430 total ankle replacements, where 430 developed peri-prosthetic cystic osteolysis. A statistically significant association (P<.001) was found between the presence of bone cysts and non-anatomic implant configuration, hydroxyapatite-coating, mobile-bearing and non tibial-stemmed implants. No significant association existed between the type of constraining and the presence of cysts (P>.05). Conclusions: Non-anatomic, mobile-bearing, hydroxyapatite-coated and non tibial-stemmed total ankle replacements are positively associated with more periprosthetic bone cysts.engHCC ORTAnkle Joint / diagnostic imagingAnkle Joint / surgeryArthroplasty, Replacement, Ankle / adverse effectsBone Cysts / diagnosisBone Cysts / etiologyBone Cysts / surgeryHumansJoint Prosthesis / adverse effectsPostoperative ComplicationsTomography, X-Ray Computedjournal article10.1016/j.fas.2017.11.002.