Aguiar, LMatos, AGil, AAfonso, CAlmeida, SBraga, LLavinha, JKjollerstrom, PFaustino, PBicho, MInácio, A2017-11-142017-11-142016Clin Hemorheol Microcirc. 2016;64(4):957-963http://hdl.handle.net/10400.17/2799Sickle cell anemia (SCA) is an inherited blood disorder. SCA patients present clinical and hematologic variability that cannot be only explained by the single mutation in the beta-globin gene. Others genetic modifiers and environmental effects are important for the clinical phenotype. SCA patients present arginine deficiency that contributes to a lower nitric oxide (NO) bioactivity.engAdolescentAdultAnemia, Sickle CellChildChild, PreschoolFemaleHumansMaleNitric OxidePolymorphism, GeneticQuality of LifeYoung AdultHDE HEM PEDHDE GENjournal article10.3233/CH-168008