Ponte, PSerrão, VViana, IVale, EJoão, ACerroni, L2013-02-012013-02-012011J Cutan Pathol. 2011 Mar;38(3):301-5http://hdl.handle.net/10400.17/1006CD30+ cutaneous lymphoproliferative disorders (CLPDs) are usually characterized by a benign clinical course. The prognostic value of cytotoxic markers in these lymphomas has not been evaluated in large series. We describe a case of borderline CD30+ CLPD with cytotoxic phenotype, presenting in a 22-year-old male patient as an ulcer on the forearm. He reported having had similar ulcers on the buttock and thigh that spontaneously regressed over the course of 1 year. The lesion resolved with a single course of clarithromycin; a subsequent lesion, too, responded to clarithromycin, and no recurrences or systemic involvement have been documented in the 9-month follow-up. A conservative approach in the management of CD30+ CLPD is recommended. We believe that the anti-inflammatory and apoptotic effects of clarithromycin on T cells may have hastened the remission process.engAnti-InflamatóriosAntigénio CD30ClaritromicinaLinfoma Cutâneo de Células TNeoplasias da PeleMarcadores Biológicos de Tumorjournal article