Reschke, FLanzinger, SHerczeg, VPrahalad, PSchiaffini, RMul, DClapin, HZabeen, BPelicand, JPhillip, MLimbert, CDanne, TAlonso, GTRhodes, ETDavis, EVeeze, HJMaahs, DCardona-Hernandez, RSumnik, ZCorathers, SBratina, NDanne, TGevers, EImane, ZPiccini, BForsander, GPacaud, DMaffeis, CCampbell, FBonfanti, Rde Sanctis, LKrone, REToth-Heyn, PWitsch, MArsanoglu, IJefferies, CLandry, ABeltrand, JAmed, SRami-Merhar, BBarat, PSzypowska, AZabeen, BCasteels, KSavova, RCherubini, Vde Bock, MTodorovic, SLimbert, CMoravej, HPozgaj Sepac, MMazur, AGerasimidou-Vazeou, AIotova, VO’Riordan, SChobot, AHerbst, ANgwu, UCody, DBirkebæk, NHHanas, RGoksen, DSarda, AChobot, JMirante, ARichmond Padilla, ETsiroukidou, KSaboo, BKanaka-Gantenbein, CSchiaffini, RFoskett, DJali, SVerkauskiene, RCastro-Correia, CKumar Guness, PPelicand, JCotterill, AKumari Mohan, MSpehar Uroic, AGoss, PSvensson, JRamchandani, GDCoutant, RMantilla, LSima, AHyun Kim, JGalli-Tsinopoulou, ARibeiro, RO’Gorman, CFonna, HBratke, HEl Habashy, SGokalani, RScharf Pinto, MChavda, V2023-12-292023-12-292022Diabetes Care . 2022 Nov 1;45(11):2594-2601http://hdl.handle.net/10400.17/4770Objective: To analyze whether the coronavirus disease 2019 (COVID-19) pandemic increased the number of cases or impacted seasonality of new-onset type 1 diabetes (T1D) in large pediatric diabetes centers globally. Research design and methods: We analyzed data on 17,280 cases of T1D diagnosed during 2018-2021 from 92 worldwide centers participating in the SWEET registry using hierarchic linear regression models. Results: The average number of new-onset T1D cases per center adjusted for the total number of patients treated at the center per year and stratified by age-groups increased from 11.2 (95% CI 10.1-12.2) in 2018 to 21.7 (20.6-22.8) in 2021 for the youngest age-group, <6 years; from 13.1 (12.2-14.0) in 2018 to 26.7 (25.7-27.7) in 2021 for children ages 6 to <12 years; and from 12.2 (11.5-12.9) to 24.7 (24.0-25.5) for adolescents ages 12-18 years (all P < 0.001). These increases remained within the expected increase with the 95% CI of the regression line. However, in Europe and North America following the lockdown early in 2020, the typical seasonality of more cases during winter season was delayed, with a peak during the summer and autumn months. While the seasonal pattern in Europe returned to prepandemic times in 2021, this was not the case in North America. Compared with 2018-2019 (HbA1c 7.7%), higher average HbA1c levels (2020, 8.1%; 2021, 8.6%; P < 0.001) were present within the first year of T1D during the pandemic. Conclusions: The slope of the rise in pediatric new-onset T1D in SWEET centers remained unchanged during the COVID-19 pandemic, but a change in the seasonality at onset became apparent.engAdolescentCOVID-19ChildCommunicable Disease ControlPandemicsDiabetes Mellitus, Type 1* / epidemiologyGlycated HemoglobinRegistriesHDE END PEDjournal article10.2337/dc22-0278