Anselmo, MCampos Rainho, AVale, MCEstrada, JValente, RCorreia, MVieira, JPBarata, D2015-11-132015-11-132006-07J Child Neurol. 2006 Jul;21(7):618-20.http://hdl.handle.net/10400.17/2343Methadone is used in the treatment of opioid addiction. Acute intoxication can lead to severe consequences and can even be lethal. In several case reports and small series, a presumably toxic leukoencephalopathy is described resulting from inhalation of heroin. We present the case of a 3-year-old boy who ingested methadone accidentally. In a coma with acute obstructive hydrocephalus owing to massive cerebellar edema and supratentorial lesions, he was successfully treated with methylprednisolone and cerebrospinal fluid external drainage. To our knowledge, this is the first report of an encephalopathy associated with synthetic opioid intoxication.engAnalgesics, Opioid/poisoningBrain Diseases/chemically inducedBrain Diseases/pathologyBrain Diseases/therapyMethadone/poisoningNeurotoxicity Syndromes/etiologyNeurotoxicity Syndromes/therapyChild, PreschoolCase ReportsHDE NEU PEDHDE UCI PEDjournal article