Abreu, RCarvalho, FViana, HMesquita, IPossante, MAires, ICaeiro, FSilva, CCotovio, PFerreira, ARemédio, FNolasco, F2021-08-132021-08-132017Clin Transplant. 2017 Apr;31(4). doi: 10.1111/ctr.12915. Epub 2017 Feb 21.http://hdl.handle.net/10400.17/3832Transplant glomerulopathy is mainly due to chronic antibody-mediated rejection and actually represents a major cause of long-term allograft failure. The lack of effective treatment remains a serious problem in transplantation. A retrospective and uni-center study was performed in 48 kidney allograft recipients with transplant glomerulopathy between January 2010 and December 2015. Median time for diagnosis was 7.1 (3.6-11.8) years post-transplant. Light microscopy showed severity of transplant glomerulopathy in the majority of patients (cg1=10.4%; cg2=20.8%; cg3=68.8%). Moderate microvascular inflammation was present in 56.3% (g+ptc≥2), and almost half of recipients (51.1%) were C4d positive in immunofluorescence. Female gender (P=.001), age (P=.043), renal dysfunction (P=.002), acute rejection episodes (P=.026), and anti-HLA class II antibodies (P=.004) were associated with kidney allograft failure. Treatment of transplant glomerulopathy was performed in 67.6% of patients. The histologic and laboratory features that led to a therapeutic intervention were score ptc (P=.021), C4d (P=.03), and the presence of anti-HLA antibodies (P=.029), whereas score ah (P=.005) was associated with conservative measure. The overall cumulative kidney allograft survival at 10 years was 75%. Treatment of transplant glomerulopathy was ineffective to improve long-term kidney allograft survival.engHCC NEFAdultFemaleMaleHumansFollow-Up StudiesMiddle AgedGlomerular Filtration RateGlomerulonephritis / etiologyGlomerulonephritis / pathologyGlomerulonephritis / therapyGraft Rejection / etiologyGraft Rejection / pathologyGraft Rejection / therapyGraft SurvivalIsoantibodies / bloodIsoantibodies / immunologyKidney Failure, Chronic / surgeryKidney Function TestsKidney Glomerulus / pathologyKidney Transplantation / adverse effectsPostoperative ComplicationsPrognosisRisk FactorsRetrospective Studiesjournal article10.1111/ctr.12915.