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Lobar Lung Transplantation: A Single-Center 10-Year Experience
Publication . Cruz, Z; Neri, F; Roxo, M; Figueiredo, C; Moita, C; Costa, AR; Santos Silva, J; Reis, J; Maciel Barbosa, J; Calvinho, P; Semedo, L
Background: The shortage of donors for lung transplants is the main limitation of the preceding. Lobar transplantation is an alternative especially useful in patients with short stature and small thoracic cavities. The aim of this study was to perform a descriptive analysis of Portuguese patients who underwent lobar lung transplantation.
Methods: A retrospective study was conducted, and patients submitted to lobar lung transplantation from January 2012 to December 2023 were evaluated. A descriptive analysis was made, including demographic data, lung diseases, waiting list dynamics, pre-transplant evaluations, and post-transplant outcomes.
Results: Sixteen lobar transplants were performed with a predominance of female patients and a median age of 47 years. Most patients had interstitial lung disease or bronchiectasis either due to cystic fibrosis or non-cystic fibrosis. The median predicted total lung capacity (pTLC) ratio was 0.73. The median waiting list time was 6 months with 9 urgent transplants and 1 emergent lobar retransplant. Extracorporeal membrane oxygenation (ECMO) was used in pre-, intra-, and postoperative periods. Most transplanted lobes were the median lobe (ML) + right upper lobe (RUL) and left upper lobe (LUL). The median length of stay was 58 days, with complications such as PDG grade 3, bronchial tree ischemia, and concentrical stenosis of bronchial anastomosis. Six patients died in this period, 1 in the immediate postoperative period and 5 during the post-transplant hospitalization, with a median survival of 20.7 months and a 1-year and 5-year survival rate of 60%.
Conclusion: Our results show a population with an increased waiting list converging in many urgent cases, with an early mortality and high primary graft dysfunction rate. Nevertheless, mid- and long-term survival are promising.
To Keep Watching or Let It Go: Can We Achieve an Optimal Trade Off Between Costs and Effectiveness for Post-EVAR Follow Up?
Publication . D’Oria, M; Bastos Gonçalves, F
Basilar Artery Occlusion Management: Specialist Perspectives From an International Survey
Publication . Edwards, C; Drumm, B; Siegler, J; Schonewille, W; Klein, P; Huo, X; Chen, Y; Abdalkader, M; Qureshi, M; Strbian, D; Liu, X; Hu, W; Ji, X; Li, C; Fischer, U; Nagel, S; Puetz, V; Michel, P; Alemseged, F; Sacco, S; Yamagami, H; Yaghi, S; Strambo, D; Kristoffersen, E; Sandset, E; Mikulik, R; Tsivgoulis, G; Masoud, H; Aguiar de Sousa, D; Marto, JP; Lobotesis, K; Roi, D; Berberich, A; Demeestere, J; Meinel, T; Rivera, R; Poli, S; Ton, M; Zhu, Y; Li, F; Sang, H; Thomalla, G; Parsons, M; Campbell, B; Zaidat, O; Chen, HS; Field, T; Raymond, J; Kaesmacher, J; Nogueira, R; Jovin, T; Sun, D; Liu, R; Qureshi, A; Qiu, Z; Miao, Z; Banerjee, S; Nguyen, T
Background and purpose: Two early basilar artery occlusion (BAO) randomized controlled trials did not establish the superiority of endovascular thrombectomy (EVT) over medical management. While many providers continue to recommend EVT for acute BAO, perceptions of equipoise in randomizing patients with BAO to EVT versus medical management may differ between clinician specialties.
Methods: We conducted an international survey (January 18, 2022 to March 31, 2022) regarding management strategies in acute BAO prior to the announcement of two trials indicating the superiority of EVT, and compared responses between interventionalists (INTs) and non-interventionalists (nINTs). Selection practices for routine EVT and perceptions of equipoise regarding randomizing to medical management based on neuroimaging and clinical features were compared between the two groups using descriptive statistics.
Results: Among the 1245 respondents (nINTs = 702), INTs more commonly believed that EVT was superior to medical management in acute BAO (98.5% vs. 95.1%, p < .01). A similar proportion of INTs and nINTs responded that they would not randomize a patient with BAO to EVT (29.4% vs. 26.7%), or that they would only under specific clinical circumstances (p = .45). Among respondents who would recommend EVT for BAO, there was no difference in the maximum prestroke disability, minimum stroke severity, or infarct burden on computed tomography between the two groups (p > .05), although nINTs more commonly preferred perfusion imaging (24.2% vs. 19.7%, p = .04). Among respondents who indicated they would randomize to medical management, INTs were more likely to randomize when the National Institutes of Health Stroke Scale was ≥10 (15.9% vs. 6.9%, p < .01).
Conclusions: Following the publication of two neutral clinical trials in BAO EVT, most stroke providers believed EVT to be superior to medical management in carefully selected patients, with most indicating they would not randomize a BAO patient to medical treatment. There were small differences in preference for advanced neuroimaging for patient selection, although these preferences were unsupported by clinical trial data at the time of the survey.
Estágios de Grupo I do Internato de Anestesiologia: Uma Perspetiva Atual
Publication . Roxo, M; Mamede, M; Vieira, I; Chen, J
Introdução: A especialidade de Anestesiologia prima pela prática baseada na evidência e cuidado com a formação. Os estágios de grupo I são a mais recente alteração ao programa formativo da especialidade, tendo-se realizado pela primeira vez em janeiro de 2020.
Material e Métodos: Realizou-se um estudo observacional transversal descritivo com base num inquérito on-line com o objetivo de definir, segundo a perceção dos Médicos Internos, a qualidade, utilidade e recursos logísticos do estágio. O inquérito era composto por 14 questões, divididas em dois grupos: um bloco relativo à componente formativa e laboral e um bloco relativo à componente logística do estágio.
Resultados: De um universo de 160 Internos de Formação
Especializada em Anestesiologia foram obtidas 75 respostas (46,9%). Os estágios de grupo I demonstraram ser uma mais-valia no Internato de Anestesiologia. Os médicos internos, na sua grande maioria, apresentam um elevado grau de satisfação com o estágio, autonomia e variedade de funções desempenhadas, que culminam na vontade de exercer futuramente funções em hospitais distritais.
Conclusão: Esta análise dos dois primeiros anos do estágio de grupo I pode servir de base para uma discussão alargada que poderá conduzir a um processo de contínua melhoria de condições e eventual introdução de novos elementos num estágio que já demonstrou ser vantajoso para os elementos envolvidos.
Endocardite com Nódulos e Lesões Janeway
Publication . Cruz, L; Pereira de Sousa, J