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Browsing by Author "Caldeira, F"

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  • Cross-Protection to New Drifted Influenza A(H3) Viruses and Prevalence of Protective Antibodies to Seasonal Influenza, During 2014 in Portugal
    Publication . Guiomar, R; Pereira da Silva, S; Conde, P; Cristóvão, P; Maia, AC; Pechirra, P; Rodrigues, AP; Nunes, B; Milho, L; Coelho, AP; Fernandes, A; Caseiro, P; Rodrigues, F; Correia, L; Pereira-Vaz, J; Almeida, S; Branquinho, P; Côrte-Real, R; Viseu, R; Peres, MJ; Sanches, R; Dantas, F; Freitas, L; Andrade, G; Maurílio, M; Caldeira, F; Cabral Veloso, R; Mota-Vieira, L; Soares, M; Couto, AR; Bruges-Armas, J; Mouro Pinto, R; Sobrinho Simões, J; Costa, MR; Guimarães, JT; Martins, L; Cunha, M
    INTRODUCTION: Immune profile for influenza viruses is highly changeable over time. Serological studies can assess the prevalence of influenza, estimate the risk of infection, highlight asymptomatic infection rate and can also provide data on vaccine coverage. The aims of the study were to evaluate pre-existing cross-protection against influenza A(H3) drift viruses and to assess influenza immunity in the Portuguese population. MATERIALS AND METHODS: We developed a cross-sectional study based on a convenience sample of 626 sera collected during June 2014, covering all age groups, both gender and all administrative health regions of Portugal. Sera antibody titers for seasonal and new A(H3) drift influenza virus were evaluated by hemagglutination inhibition assay (HI). Seroprevalence to each seasonal influenza vaccine strain virus and to the new A(H3) drift circulating strain was estimated by age group, gender and region and compared with seasonal influenza-like illness (ILI) incidence rates before and after the study period. RESULTS: Our findings suggest that seroprevalences of influenza A(H3) (39.9%; 95% CI: 36.2-43.8) and A(H1)pdm09 (29.7%; 95% CI: 26.3-33.4) antibodies were higher than for influenza B, in line with high ILI incidence rates for A(H3) followed by A(H1)pdm09, during 2013/2014 season. Low pre-existing cross-protection against new A(H3) drift viruses were observed in A(H3) seropositive individuals (46%). Both against influenza A(H1)pdm09 and A(H3) seroprotection was highest in younger than 14-years old. Protective antibodies against influenza B were highest in those older than 65years old, especially for B/Yamagata lineage, 33.3% (95% CI: 25.7-41.9). Women showed a high seroprevalence to influenza, although without statistical significance, when compared to men. A significant decreasing trend in seroprotection from north to south regions of Portugal mainland was observed. CONCLUSIONS: Our results emphasize that low seroprotection increases the risk of influenza infection in the following winter season. Seroepidemiological studies can inform policy makers on the need for vaccination and additional preventive measures.
    2017Journal article Open access Show more
  • Osteossarcoma Extraesquelético Retroperitoneal, um Caso Raro
    Publication . Morgado, MC; Caldeira, F; Baptista, J; Gôja, M; Andrade, D
    Homem de 75 anos, com história de perda ponderal (>10% peso inicial) nos sete meses anteriores, presença de massa abdominal no flanco esquerdo com dor tipo moinha, associadas a queixas de anorexia não selectiva e enfartamento pós-prandial, com três meses de evolução. Antecedentes de adenocarcinoma do estômago e adenocarcinoma do cólon. Submetido a intervenção cirúrgica, tendo-se ressecado peça volumosa, constituída por células malignas, com componente quístico e componente sólido (tecido fibroso, cartilagem e osso maduro). O exame da anatomia patológica concluiu tratar-se de um Osteossarcoma Extraesquelético Retroperitoneal Telangiectásico. Clínica e laboratorialmente sem alterações na reavaliação aos doze meses de pós-operatório. Os exames complementares de diagnóstico, nesta data, não revelaram recidiva local ou metastização.
    2010Journal article Open access Show more