Browsing by Author "Melancia, D"
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- Choroidal Thinning: Alzheimer's Disease and AgingPublication . Cunha, JP; Proença, R; Dias-Santos, A; Melancia, D; Almeida, R; Águas, H; Oliveira Santos, B; Alves, M; Ferreira, J; Papoila, AL; Louro, C; Castanheira-Dinis, AINTRODUCTION: The purpose of this study was to measure and to compare macular choroidal thickness (CT) between patients with mild Alzheimer's disease (AD), patients without AD, and elderly patients. METHODS: CT was measured manually in 13 locations at 500-μm intervals of a horizontal and a vertical section from the fovea. Linear regression models were used to analyze the data. RESULTS: Fifty patients with a diagnosis of mild AD (73.1 years), 152 patients without AD (71.03 years), and 50 elderly without AD (82.14 years) were included. In the AD patients, CT was significantly thinner in all 13 locations (P < .001-comparing with age-match group), and comparing with the elderly group, a more pronounced difference was found in two locations temporal to the fovea. DISCUSSION: Patients with AD showed a significant choroidal thinning even when compared with elderly subjects. The reduction of CT may aid in the diagnoses of AD, probably reflecting the importance of vascular factors in their pathogenesis.
- Diabetic Choroidopathy: a Review of the Current LiteraturePublication . Melancia, D; Vicente, A; Cunha, JP; Abegão Pinto, L; Ferreira, JDiabetic retinopathy is an increasingly prevalent disease, and a leading contributor to the burden of all-cause blindness worldwide. In addition to retinal changes, choroidal abnormalities are common in patients with diabetes. The first studies concerning this vascular structure were based on histologic, indocyanine angiography and laser Doppler flowmetry techniques, but the development of new optical coherence tomography (OCT) technologies and imaging software for enhanced depth imaging (EDI)-OCT in recent years has made it possible to provide more detailed images of the choroidal anatomy and topography.In diabetic patients, several choroidal changes have been described in the literature throughout the years; the recent focus is choroidal thickness, which is significantly different from that in healthy patients. However, understanding choroidal manifestations of diabetic eye disease remains a real challenge, and this gap is hindering efforts towards better defining choroidal evaluation as a predictive factor for disease evolution and treatment response.This review aims to summarize the recent literature concerning changes in choroidal structure in diabetic patients, the relationship to diabetic retinal disease progression, and finally, the current and potential application of the measurement of variations in choroidal thickness for patient management.
- Downbeat Nystagmus in Episodic Ataxia Type 1 Associated with a Novel KCNA1 MutationPublication . Jorge, A; Melancia, D; Figueiredo, C; Galego, O; Oliveira, J; Martins, AI; Lemos, J
- Influence of Weather on Seizure Frequency - Clinical Experience in the Emergency Room of a Tertiary HospitalPublication . Brás, P; Barros, A; Vaz, S; Sequeira, J; Melancia, D; Fernandes, A; de Sousa, A; Dias, S; Menezes Cordeiro, I; Manita, M