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Browsing by Author "Regateiro, F"

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  • ARIA 2019: An Integrated Care Pathway for Allergic Rhinitis in Portugal
    Publication . Fonseca, J; Taveira-Gomes, T; Pereira, AM; Branco-Ferreira, M; Carreiro-Martins, P; Alves-Correia, M; Correia de Sousa, J; Costa, E; Lourenço, O; Morais-Almeida, M; Morête, A; Regateiro, F; Todo Bom, A; Bachert, C; Pfaar, O; Wallace, D; Bedbrook, A; Czarlewski, W; Bousquet, J
    The Allergic Rhinitis and Its Impact on Asthma (ARIA) initiative started more than 20 years ago and has developed and disseminated evidence-based guidelines and projects in the field of allergic rhinitis. This initiative is currently focused on providing patient-centred guidelines that contribute to an integrated care pathway between the various levels of care and take advantage of digital solutions, and the introduction of integrated care pathways in clinical practice has been recommended. In this article we describe the adaptation for Portugal of the ARIA Integrated Care Pathways document. After a brief review of the epidemiology and impact of allergic rhinitis in Portugal and the activities carried out in Portugal within the ARIA initiative, we describe the broad knowledge base used for the development of recommendations for the pharmacological treatment of allergic rhinitis, and these recommendations are based on the GRADE methodology, real world evidence acquired by mobile technology (mHealth) and resulting from allergenic exposure chamber studies. What follows is a summary of integrated care pathways for allergen immunotherapy produced in 2019. Allergen immunotherapy is considered an example of precision medicine where the use of mHealth technologies will improve stratification for patient selection and response monitoring. These recommendations were considered as best practices of integrated patient-centred care supported by digital systems from Directorate General for Health and Food Safety of the European Union (DG Santé) and represent the ARIA Phase 4 Change Management strategy.
    2021-02-01Journal article Open access Show more
  • ARIA Digital Anamorphosis: Digital Transformation of Health and Care in Airway Diseases from Research to Practice
    Publication . Bousquet, J; Anto, JM; Bachert, C; Haahtela, T; Zuberbier, T; Czarlewski, W; Bedbrook, A; Bosnic-Anticevich, S; Walter Canonica, G; Cardona, V; Costa, E; Costa, DJ; Courbis, AL; Custovic, A; Cvetkosvki, B; D'Amato, G; da Silva, J; Dantas, C; Dokic, D; Dauvilliers, Y; De Feo, G; Cruz, AA; De Vries, G; Devillier, P; Di Capua, S; Dray, G; Dubakiene, R; Durham, SR; Dykewicz, M; Ebisawa, M; Gaga, M; El-Gamal, Y; Erhola, M; Heffler, E; Emuzyte, R; Farrell, J; Fauquert, JL; Fiocchi, A; Fink-Wagner, A; Fontaine, JF; Fuentes Perez, JM; Gemicioğlu, B; Gamkrelidze, A; Fokkens, WJ; Garcia-Aymerich, J; Gevaert, P; Gomez, RM; González Diaz, S; Gotua, M; Guldemond, NA; Guzmán, MA; Hajjam, J; Huerta Villalobos, YR; Humbert, M; Fonseca, JA; Iaccarino, G; Ierodiakonou, D; Iinuma, T; Jassem, E; Joos, G; Jung, K; Kaidashev, I; Kalayci, O; Kardas, P; Keil, T; Illario, M; Khaitov, M; Khaltaev, N; Kleine-Tebbe, J; Kouznetsov, R; Kull, I; La Grutta, S; Leonardini, L; Ljungberg, H; Lieberman, P; Lipworth, B; Ivancevich, JC; Lodrup Carlsen, K; Lopes-Pereira, C; Loureiro, C; Louis, R; Mair, A; Mahboub, B; Makris, M; Malva, J; Manning, P; Marshall, G; Jutel, M; Masjedi, M; Carreiro-Martins, P; Makela, M; Mathieu-Dupas, E; Maurer, M; De Manuel Keenoy, E; Melo-Gomes, E; Meltzer, E; Menditto, E; Mercier, J; Klimek, L; Micheli, Y; Miculinic, N; Mihaltan, F; Milenkovic, B; Mitsias, D; Moda, G; Mogica-Martinez, MD; Mohammad, Y; Montefort, S; Monti, R; Kuna, P; Morais-Almeida, M; Mösges, R; Münter, L; Muraro, A; Murray, R; Naclerio, R; Napoli, L; Namazova-Baranova, L; Neffen, H; Nekam, K; Kvedariene, V; Neou, A; Nordlund, B; Novellino, E; Nyembue, D; O'Hehir, R; Ohta, K; Okubo, K; Onorato, G; Orlando, V; Ouedraogo, S; Le, L; Palamarchuk, J; Pali-Schöll, I; Panzner, P; Park, H; Passalacqua, G; Pépin, JL; Paulino, E; Pawankar, R; Phillips, J; Picard, R; Larenas-Linnemann, DE; Pinnock, H; Plavec, D; Popov, T; Portejoie, F; Price, D; Prokopakis, E; Psarros, F; Pugin, B; Puggioni, F; Quinones-Delgado, P; Laune, D; Raciborski, F; Rajabian-Söderlund, R; Regateiro, F; Reitsma, S; Rivero-Yeverino, D; Roberts, G; Roche, N; Rodriguez-Zagal, E; Rolland, C; Roller-Wirnsberger, R; Lourenço, OM; Rosario, N; Romano, A; Rottem, M; Ryan, D; Salimäki, J; Sanchez-Borges, M; Sastre, J; Scadding, G; Scheire, S; Schmid-Grendelmeier, P; Melén, Erik; Schünemann, H; Sarquis Serpa, F; Shamji, M; Sisul, JC; Sofiev, M; Solé, D; Somekh, D; Sooronbaev, T; Sova, M; Spertini, F; Mullol, J; Spranger, O; Stellato, C; Stelmach, R; Thibaudon, M; To, T; Toumi, M; Usmani, O; Valero, A; Valenta, R; Valentin-Rostan, M; Niedoszytko, M; Pereira, M; van der Kleij, R; Van Eerd, M; Vandenplas, O; Vasankari, T; Vaz Carneiro, A; Vezzani, G; Viart, F; Viegi, G; Wallace, D; Odemyr, M; Wagenmann, M; Wang, Y; Waserman, S; Wickman, M; Williams, D; Wong, G; Wroczynski, P; Yiallouros, P; Yusuf, O; Zar, HJ; Okamoto, Y; Zeng, S; Zernotti, ME; Zhang, L; Shan Zhong, N; Papadopoulos, NG; Patella, V; Pfaar, O; Pham-Thi, N; Rolland, C; Samolinski, B; Sheikh, A; Sofiev, M; Suppli Ulrik, C; Todo-Bom, A; Tomazic, PV; Toppila-Salmi, S; Tsiligianni, I; Valiulis, A; Valovirta, E; Ventura, MT; Walker, S; Williams, S; Yorgancioglu, A; Agache, I; Akdis, CA; Almeida, R; Ansotegui, IJ; Annesi-Maesano, I; Arnavielhe, S; Basagaña, X; D Bateman, E; Bédard, A; Bedolla-Barajas, M; Becker, S; Bennoor, KS; Benveniste, S; Bergmann, KC; Bewick, M; Bialek, S; E Billo, N; Bindslev-Jensen, C; Bjermer, L; Blain, H; Bonini, M; Bonniaud, P; Bosse, I; Bouchard, J; Boulet, LP; Bourret, R; Boussery, K; Braido, F; Briedis, V; Briggs, A; Brightling, CE; Brozek, J; Brusselle, G; Brussino, L; Buhl, R; Buonaiuto, R; Calderon, MA; Camargos, P; Camuzat, T; Caraballo, L; Carriazo, AM; Carr, W; Cartier, C; Casale, T; Cecchi, L; Cepeda Sarabia, AM; H Chavannes, N; Chkhartishvili, E; Chu, DK; Cingi, C; Correia de Sousa, J
    Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.
    2021Journal article Open access Show more
  • [Letter to the Editor: Primary Immunodeficiencies in Adults - Multicentric Cooperation to Characterize the Portuguese Reality]
    Publication . Duarte Ferreira, R; Silva, S; Carrapatoso, I; Regateiro, F; Santos, N; Silva, D; Sousa, F; Oliveira, S; Paiva, M; Torres da Costa, J; Câmara, R; Faria, E; Lopes da Silva, S
    2018-04-30Journal article Open access Show more
  • PROP1 Gene Analysis in Portuguese Patients with Combined Pituitary Hormone Deficiency
    Publication . Lemos, MC; Gomes, L; Bastos, M; Leite, V; Limbert, E; Carvalho, D; Bacelar, C; Monteiro, M; Fonseca, F; Agapito, A; Castro, JJ; Regateiro, F; Carvalheiro, M
    OBJECTIVE: Mutations of the PROP1 gene lead to combined pituitary hormone deficiency (CPHD), which is characterized by a deficiency of GH, TSH, LH/FSH, PRL and, less frequently, ACTH. This study was undertaken to investigate the molecular defect in a cohort of patients with CPHD. DESIGN, PATIENTS AND MEASUREMENTS: A multicentric study involving 46 cases of CPHD (17 familial cases belonging to seven kindreds and 29 sporadic cases) selected on the basis of clinical and hormonal evidence of GH deficiency, central hypothyroidism and hypogonadotrophic hypogonadism, in the absence of an identified cause of hypopituitarism. Mutations of PROP1 were investigated by DNA sequencing. Clinical, hormonal and neuroradiological data were collected at each centre. RESULTS: PROP1 mutations were identified in all familial cases: five kindreds presented a c. 301-302delAG mutation, one kindred presented a c. 358C --> T (R120C) mutation and one presented a previously unreported initiation codon mutation, c. 2T --> C. Of the 29 sporadic cases, only two (6.9%) presented PROP1 germline mutations (c. 301-302delAG, in both). Phenotypic variability was observed among patients with the same mutations, particularly the presence and age of onset of hypocortisolism, the levels of PRL and the results of pituitary imaging. One patient presented a sellar mass that persisted into adulthood. CONCLUSIONS: This is the first report of a mutation in the initiation codon of the PROP1 gene and this further expands the spectrum of known mutations responsible for CPHD. The low mutation frequency observed in sporadic cases may be due to the involvement of other unidentified acquired or genetic causes.
    2006-10Journal article Open access Show more