Focal Malignant Liver Lesions: Diagnosis by Dynamic Incremental CT, Early Phase

Marques, RM; Mendonça, P; Cordeiro, A; Monteiro, T; Vilela, J; Almeida, F

http://hdl.handle.net/10400.17/1254

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Eur Radiol 1996 433.pdf		1.78 MB	Adobe PDF	Download

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Abstract(s)

The purpose of our study was to evaluate the accuracy of dynamic incremental bolus-enhanced conventional CT (DICT) with intravenous contrast administration, early phase, in the diagnosis of malignancy of focal liver lesions. A total of 122 lesions were selected in 74 patients considering the following criteria: lesion diameter 10 mm or more, number of lesions less than six per study, except in multiple angiomatosis and the existence of a valid criteria of definitive diagnosis. Lesions were categorized into seven levels of diagnostic confidence of malignancy compared with the definitive diagnosis for acquisition of a receiver-operator-characteristic (ROC) curve analysis and to determine the sensitivity and specificity of the technique. Forty-six and 70 lesions were correctly diagnosed as malignant and benign, respectively; there were 2 false-positive and 4 false-negative diagnoses of malignancy and the sensitivity and specificity obtained were 92 and 97%. The DICT early phase was confirmed as a highly accurate method in the characterization and diagnosis of malignancy of focal liver lesions, requiring an optimal technical performance and judicious analysis of existing semiological data.

Keywords

Angiomatose Intervalos de Confiança Meios de Contraste Diagnóstico Diferencial Estudos de Follow-Up Injecções Intravenosas Doenças do Fígado Neoplasias Hepáticas Estudos Prospectivos Curva ROC Intensificação de Imagem Radiográfica Sensibilidade e Especificidade Tomografia Computorizada