Publication
Timing of Disease Occurrence and Hepatic Resection on Long-Term Outcome of Patients with Neuroendocrine Liver Metastasis
| dc.contributor.author | Zhang, XF | |
| dc.contributor.author | Beal, EW | |
| dc.contributor.author | Weiss, M | |
| dc.contributor.author | Aldrighetti, L | |
| dc.contributor.author | Poultsides, GA | |
| dc.contributor.author | Bauer, TW | |
| dc.contributor.author | Fields, RC | |
| dc.contributor.author | Maithel, SK | |
| dc.contributor.author | Pinto Marques, H | |
| dc.contributor.author | Pawlik, TM | |
| dc.date.accessioned | 2020-08-05T17:34:08Z | |
| dc.date.available | 2020-08-05T17:34:08Z | |
| dc.date.issued | 2018-02 | |
| dc.description.abstract | Background and objectives: The objective of the study was to evaluate the impact of timing of disease occurrence and hepatic resection on long-term outcome of neuroendocrine liver metastasis (NELM). Methods: A total of 420 patients undergoing curative-intent resection for NELM were identified from a multi-institutional database. Date of primary resection, NELM detection and resection, intraoperative details, disease-specific (DSS), and recurrence-free survival (RFS) were obtained. Results: A total of 243 (57.9%) patients had synchronous NELM, while 177 (42.1%) developed metachronous NELM. On propensity score matching (PSM), patients with synchronous versus metachronous NELM had comparable DSS (10-year DSS, 76.2% vs 85.9%, P = 0.105), yet a worse RFS (10-year RFS, 34.1% vs 59.8%, P = 0.008). DSS and RFS were comparable regardless of operative approach (simultaneous vs staged, both P > 0.1). Among patients who developed metachronous NELM, no difference in long-term outcomes were identified between early (≤2 years, n = 102, 57.6%) and late (>2 years, n = 68, 42.4%) disease on PSM (both P > 0.1). Conclusions: Patients with synchronous NELM had a higher risk of tumor recurrence after hepatic resection versus patients with metachronous disease. The time to development of metachronous NELM did not affect long-term outcome. Curative-intent hepatic resection should be considered for patients who develop NELM regardless of the timing of disease presentation. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | J Surg Oncol. 2018 Feb;117(2):171-181. | pt_PT |
| dc.identifier.doi | 10.1002/jso.24832 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.17/3485 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Wiley | pt_PT |
| dc.subject | Aged | pt_PT |
| dc.subject | Databases, Factual | pt_PT |
| dc.subject | Female | pt_PT |
| dc.subject | Follow-Up Studies | pt_PT |
| dc.subject | Hepatectomy | pt_PT |
| dc.subject | Humans | pt_PT |
| dc.subject | Incidence | pt_PT |
| dc.subject | Liver Neoplasms | pt_PT |
| dc.subject | Male | pt_PT |
| dc.subject | Middle Aged | pt_PT |
| dc.subject | Neoplasm Recurrence, Local | pt_PT |
| dc.subject | Neuroendocrine Tumors | pt_PT |
| dc.subject | Prognosis | pt_PT |
| dc.subject | Propensity Score | pt_PT |
| dc.subject | Time-to-Treatment | pt_PT |
| dc.subject | HCC CIR | pt_PT |
| dc.title | Timing of Disease Occurrence and Hepatic Resection on Long-Term Outcome of Patients with Neuroendocrine Liver Metastasis | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 181 | pt_PT |
| oaire.citation.issue | 2 | pt_PT |
| oaire.citation.startPage | 171 | pt_PT |
| oaire.citation.title | Journal of Surgical Oncology | pt_PT |
| oaire.citation.volume | 117 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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