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Determinants of HIV-1 Transmission Clusters and Transmitted Drug Resistance in Men Who Have Sex With Men: a Multicenter Study in Portugal (2014-2019).

2025-06Clinical study Open access
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dc.contributor.authorAbrantes, Ricardo
dc.contributor.authorPimentel, Victor
dc.contributor.authorSebastião, Cruz
dc.contributor.authorMiranda, Mafalda N S
dc.contributor.authorSeabra, Sofia
dc.contributor.authorSilva, Ana Rita
dc.contributor.authorDiniz, António
dc.contributor.authorAscenção, Bianca
dc.contributor.authorPiñeiro, Carmela
dc.contributor.authorKoch, Carmo
dc.contributor.authorRodrigues, Catarina
dc.contributor.authorCaldas, Cátia
dc.contributor.authorMorais, Célia
dc.contributor.authorFaria, Domitília
dc.contributor.authorSilva, Elisabete Gomes
dc.contributor.authorTeófilo, Eugénio
dc.contributor.authorMonteiro, Fátima
dc.contributor.authorRoxo, Fausto
dc.contributor.authorMaltez, Fernando
dc.contributor.authorRodrigues, Fernando
dc.contributor.authorGaião, Guilhermina
dc.contributor.authorRamos, Helena
dc.contributor.authorCosta, Inês
dc.contributor.authorDiogo, Isabel
dc.contributor.authorGermano, Isabel
dc.contributor.authorSimões, Joana
dc.contributor.authorOliveira, Joaquim
dc.contributor.authorFerreira, José
dc.contributor.authorPoças, José
dc.contributor.authorda Cunha, José Saraiva
dc.contributor.authorSoares, Jorge
dc.contributor.authorMansinho, Kamal
dc.contributor.authorPedro, Liliana
dc.contributor.authorAleixo, Maria João
dc.contributor.authorGonçalves, Maria João
dc.contributor.authorManata, Maria José
dc.contributor.authorMouro, Margarida
dc.contributor.authorSerrado, Margarida
dc.contributor.authorCaixeiro, Micaela
dc.contributor.authorMarques, Nuno
dc.contributor.authorCosta, Olga
dc.contributor.authorPacheco, Patrícia
dc.contributor.authorProença, Paula
dc.contributor.authorRodrigues, Paulo
dc.contributor.authorPinho, Raquel
dc.contributor.authorTavares, Raquel
dc.contributor.authorde Abreu, Ricardo Correia
dc.contributor.authorCôrte-Real, Rita
dc.contributor.authorSerrão, Rosário
dc.contributor.authorSarmento E Castro, Rui
dc.contributor.authorNunes, Sofia
dc.contributor.authorFaria, Telo
dc.contributor.authorBaptista, Teresa
dc.contributor.authorSimões, Daniel
dc.contributor.authorMendão, Luis
dc.contributor.authorMartins, M Rosário O
dc.contributor.authorGomes, Perpétua
dc.contributor.authorPingarilho, Marta
dc.contributor.authorAbecasis, Ana B
dc.date.accessioned2025-08-01T15:54:17Z
dc.date.available2025-08-01T15:54:17Z
dc.date.issued2025-06
dc.description.abstractIntroduction: In the EU/EEA, men who have sex with men (MSM) is a priority group for the prevention and control of HIV-1 infection. In Portugal, the 2023 HIV incidence rate was 8.2 per 100,000 inhabitants, with 876 new infections, 41.7% in MSM. We aim to characterize HIV-1 transmission clusters (TC) and transmitted drug resistance (TDR) and its sociodemographic, behavioral, clinical, and viral genomic determinants in MSM newly diagnosed in Portugal between 2014 and 2019. Methods: A total of 340 MSM newly diagnosed with HIV-1 infection at 17 hospitals in Portugal were included. TC was identified with branch support ≥90% and 1.5% genetic distance. Logistic regression models were used to examine factors associated with TC and TDR. Results: We identified 38 TC with 104 MSM, which includes 81 (26.6%) of the 305 MSM from our sample included in cluster analysis. The overall prevalence of TDR was 8.2%. Only HIV-1 subtype C was significantly associated with TDR. Overall, 10.5% of the clusters had at least 1 surveillance drug resistance mutation. There was no significant difference in the prevalence of TDR or the proportion of Portuguese and migrant MSM inside and outside clusters. Age at diagnosis, district of residence, unprotected sex with a woman, HIV testing, presenter status, and HIV-1 subtype were significantly associated with TC. Conclusion: Specific subgroups of MSM are contributing to HIV-1 clustered transmission in Portugal. However, no association was found between TDR and sociodemographic or behavioral factors. Directed prevention measures should focus on those subgroups.eng
dc.identifier.citationInt J Infect Dis . 2025 Jun:155:107888. doi: 10.1016/j.ijid.2025.107888.
dc.identifier.doi10.1016/j.ijid.2025.107888.
dc.identifier.pmid40107342
dc.identifier.urihttp://hdl.handle.net/10400.17/5132
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHSJ MED
dc.subjectHSAC MED
dc.subjectHCC INF
dc.subjectAdult
dc.subjectYoung Adult
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectAnti-HIV Agents / pharmacology
dc.subjectAnti-HIV Agents / therapeutic use
dc.subjectCluster Analysis
dc.subjectDrug Resistance
dc.subjectViral* / genetics
dc.subjectHIV Infections* / drug therapy
dc.subjectHIV Infections* / epidemiology
dc.subjectHIV Infections* / transmission
dc.subjectHIV Infections* / virology
dc.subjectHIV-1* / drug effects
dc.subjectHIV-1* / genetics
dc.subjectHomosexuality
dc.subjectMale* / statistics & numerical data
dc.subjectPortugal / epidemiology
dc.subjectPrevalence
dc.subjectRisk Factors
dc.titleDeterminants of HIV-1 Transmission Clusters and Transmitted Drug Resistance in Men Who Have Sex With Men: a Multicenter Study in Portugal (2014-2019).eng
dc.typeclinical study
dspace.entity.typePublication
oaire.citation.startPage107888
oaire.citation.titleInternational Journal of Infectious Diseases
oaire.citation.volume155
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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