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FEEDMI: A Study Protocol to Determine the Influence of Infant-Feeding on Very-Preterm-Infant's Gut Microbiota

2019Journal article Open access
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dc.contributor.authorMorais, J
dc.contributor.authorMarques, C
dc.contributor.authorTeixeira, D
dc.contributor.authorDurão, C
dc.contributor.authorFaria, A
dc.contributor.authorBrito, S
dc.contributor.authorCardoso, M
dc.contributor.authorMacedo, I
dc.contributor.authorTomé, T
dc.contributor.authorCalhau, C
dc.date.accessioned2022-03-10T15:42:48Z
dc.date.available2022-03-10T15:42:48Z
dc.date.issued2019
dc.description.abstractBackground: Preterm infants are especially vulnerable to gut microbiota disruption and dysbiosis since their early gut microbiota is less abundant and diverse. Several factors may influence infants' gut microbiota, such as the mother's diet, mode of delivery, antibiotic exposure, and type of feeding. Objectives: This study aims to examine the factors associated with very-preterm neonate's intestinal microbiota, namely: (1) type of infant-feeding (breast milk, donor human milk with or without bovine protein-based fortifier, and preterm formula); (2) maternal diet; and (3) mode of delivery. Methods: This is an observational study conducted in a cohort of very preterm infants hospitalized in the neonatal intensive care unit of Maternidade Dr. Alfredo da Costa. After delivery, the mothers are asked to collect their own fecal samples and are invited to complete a semiquantitative food frequency questionnaire. The maternal diet will be classified in accordance to the Mediterranean Diet adherence score. Stool samples have been collected from very premature infants every 7 days for 21 days. DNA has been extracted from the fecal samples, and different bacterial genus and species will be quantified by real-time polymerase chain reaction. Results and conclusions: It is hypothesized that significant differences in the microbiota composition and clinical outcomes of very preterm infants will be observed depending on the type of infant feeding. In addition, this study will clarify how pasteurized donor's milk influences the intestinal microbiota colonization of preterm infants. This is a pioneer study developed in collaboration with the country's Human Milk Bank. We also expect to find microbiota alterations in infants according to the mode of delivery and to maternal diet. This study will contribute to increase the evidence on the effects of breast or donor human milk and its fortification with a bovine protein-based fortifier on infant microbiota.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNeonatology. 2019;116(2):179-184.pt_PT
dc.identifier.doi10.1159/000496547.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3997
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherKargerpt_PT
dc.subjectMAC PEDpt_PT
dc.subjectMAC DIEpt_PT
dc.subjectClinical Trials as Topicpt_PT
dc.subjectDietpt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectDelivery, Obstetricpt_PT
dc.subjectFeces / microbiologypt_PT
dc.subjectFeeding Behavior*pt_PT
dc.subjectGastrointestinal Microbiome*pt_PT
dc.subjectInfant Formula*pt_PT
dc.subjectInfant Nutritional Physiological Phenomenapt_PT
dc.subjectInfant, Extremely Prematurept_PT
dc.subjectInfant, Newbornpt_PT
dc.subjectInfant, Premature*pt_PT
dc.subjectIntensive Care Units, Neonatalpt_PT
dc.subjectLongitudinal Studiespt_PT
dc.subjectMaternal Nutritional Physiological Phenomenapt_PT
dc.subjectMilk, Human*pt_PT
dc.subjectObservational Studies as Topicpt_PT
dc.subjectSurveys and Questionnairespt_PT
dc.titleFEEDMI: A Study Protocol to Determine the Influence of Infant-Feeding on Very-Preterm-Infant's Gut Microbiotapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage184pt_PT
oaire.citation.startPage179pt_PT
oaire.citation.titleNeonatologypt_PT
oaire.citation.volume116pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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