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Psychosocial Determinants of Quality of Life 6 Months After Transplantation: Longitudinal Prospective Study
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Advisor(s)
Abstract(s)
OBJECTIVES: We sought to investigate the psychosocial determinants of quality of life at 6 months after transplantation.
METHODS:
A sample of liver transplant candidates (n = 60), composed of consecutive patients (25% with familial amyloid polyneuropathy [FAP]) attending outpatient clinics was assessed in the pretransplant period using the Neo Five Factor Inventory, Hospital Anxiety and depression Scale (HADS), Brief COPE, and SF-36, a quality-of-life, self-rating questionnaire. Six months after transplantation, these patients were assessed by means of the SF-36.
RESULTS:
Psychosocial predictors where found by means of multiple regression analysis. The physical component of quality of life at 6 months after transplantation was determined based upon coping strategies and physical quality of life in the pretransplant period (this model explained 32% of variance). The mental component at 6 months after transplantation was determined by depression in the pretransplant period and by clinical diagnoses of patients. Because FAP patients show a lower mental component of quality of life, this diagnosis explained 25% of the variance.
CONCLUSIONS:
Our findings suggested that coping strategies and depression measured in the pretransplant period are important determinants of quality of life at 6 months after liver transplantation.
Description
Keywords
HCC CHBPT Adaptation, Psychological Amyloid Neuropathies, Familial/surgery Anxiety/epidemiology Depression/epidemiology Humans Liver Diseases/classification Liver Diseases/surgery Liver Transplantation/physiology Liver Transplantation/psychology Longitudinal Studies Personality Psychology Quality of Life Questionnaires Regression Analysis Retrospective Studies
Citation
Transplant Proc. 2009 Apr;41(3):898-900