Publication
Primary Antiphospholipid Syndrome: Pregnancy Outcome in a Portuguese Population
| dc.contributor.author | Serrano, F | |
| dc.contributor.author | Nogueira, I | |
| dc.contributor.author | Borges, A | |
| dc.contributor.author | Branco, J | |
| dc.date.accessioned | 2012-10-31T11:16:22Z | |
| dc.date.available | 2012-10-31T11:16:22Z | |
| dc.date.issued | 2009 | |
| dc.description.abstract | Introduction:Women with antiphospholipid syndrome(APS) may suffer from recurrent miscarriage, fetal death, fetal growth restriction (FGR), pre-eclampsia, placental abruption, premature delivery and thrombosis. Treatment with aspirin and low molecular weight heparin (LMWH) combined with close maternal-fetal surveillance can change these outcomes. Objective: To assess maternal and perinatal outcome in a cohort of Portuguese women with primary APS. Patients and Methods: A retrospective analysis of 51 women with primary APS followed in our institution (January 1994 to December 2007). Forty one(80.4%) had past pregnancy morbidity and 35.3%(n=18) suffered previous thrombotic events. In their past they had a total of 116 pregnancies of which only 13.79 % resulted in live births. Forty four patients had positive anticardiolipin antibodies and 33 lupus anticoagulant. All women received treatment with low dose aspirin and LMWH. Results: There were a total of 67 gestations (66 single and one multiple). The live birth rate was 85.1%(57/67) with 10 pregnancy failures: seven in the first and second trimesters, one late fetal death and two medical terminations of pregnancy (one APS related). Mean (± SD) birth weight was 2837 ± 812 g and mean gestational age 37 ± 3.3 weeks. There were nine cases of FGR and 13 hypertensive complications(4 HELLP syndromes). 54.4% of the patients delivered by caesarean section. Conclusions: In our cohort, early treatment with aspirin and LMWH combined with close maternal-fetal surveillance was associated with a very high chance of a live newborn. | por |
| dc.identifier.citation | Acta Reumatol Port. 2009 Jul-Sep;34(3):492-7 | por |
| dc.identifier.uri | http://hdl.handle.net/10400.17/709 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Sociedade Portuguesa de Reumatologia | por |
| dc.subject | Antiphospholipid Syndrome/therapy | por |
| dc.subject | Portugal | por |
| dc.subject | Pregnancy | por |
| dc.subject | Pregnancy Complications/therapy | por |
| dc.subject | Pregnancy Outcome | por |
| dc.subject | Retrospective Studies | por |
| dc.title | Primary Antiphospholipid Syndrome: Pregnancy Outcome in a Portuguese Population | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 497 | por |
| oaire.citation.startPage | 492 | por |
| oaire.citation.title | Acta Reumatológica Portuguesa | por |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |