Repository logo
 
Publication

Resection of Colorectal Liver Metastases After Second-Line Chemotherapy: Is It Worthwhile? A LiverMetSurvey Analysis of 6415 Patients

2017Journal article Open access
Simple item page
dc.contributor.authorAdam, R
dc.contributor.authorYi, B
dc.contributor.authorInnominato, PF
dc.contributor.authorBarroso, E
dc.contributor.authorLaurent, C
dc.contributor.authorGiuliante, F
dc.contributor.authorCapussotti, L
dc.contributor.authorLapointe, R
dc.contributor.authorRegimbeau, JM
dc.contributor.authorLopez-Ben, S
dc.contributor.authorIsoniemi, H
dc.contributor.authorHubert, C
dc.contributor.authorLin, JK
dc.contributor.authorGruenberger, T
dc.contributor.authorElias, D
dc.contributor.authorSkipenko, OG
dc.contributor.authorGuglielmi, A
dc.date.accessioned2018-03-02T15:20:23Z
dc.date.available2018-03-02T15:20:23Z
dc.date.issued2017
dc.description.abstractPURPOSE: Patient outcome after resection of colorectal liver metastases (CLM) following second-line preoperative chemotherapy (PCT) performed for insufficient response or toxicity of the first-line, is little known and has here been compared to the outcome following first-line. PATIENTS AND METHODS: From January 2005 to June 2013, 5624 and 791 consecutive patients of a prospective international cohort received 1 and 2 PCT lines before CLM resection (group 1 and 2, respectively). Survival and prognostic factors were analysed. RESULTS: After a mean follow-up of 30.1 months, there was no difference in survival from CLM diagnosis (median, 3-, and 5-year overall survival [OS]: 58.6 months, 76% and 49% in group 2 versus 58.9 months, 71% and 49% in group 1, respectively, P = 0.32). After hepatectomy, disease-free survival (DFS) was however shorter in group 2: 17.2 months, 27% and 15% versus 19.4 months, 32% and 23%, respectively (P = 0.001). Among the initially unresectable patients of group 1 and 2, no statistical difference in OS or DFS was observed. Independent predictors of worse OS in group 2 were positive primary lymph nodes, extrahepatic disease, tumour progression on second line, R2 resection and number of hepatectomies/year <50. Positive primary nodes, synchronous and bilateral metastases were predictors of shorter DFS. Initial unresectability did not impact OS or DFS in group 2. CONCLUSION: CLM resection following second-line PCT, after oncosurgically favourable selection, could bring similar OS compared to what observed after first-line. For initially unresectable patients, OS or DFS is comparable between first- and second-line PCT. Surgery should not be denied after the failure of first-line chemotherapy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur J Cancer. 2017 Jun;78:7-15pt_PT
dc.identifier.doi10.1016/j.ejca.2017.03.009pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/2922
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectAntibodies, Monoclonalpt_PT
dc.subjectAntineoplastic Combined Chemotherapy Protocolspt_PT
dc.subjectCamptothecinpt_PT
dc.subjectCatheter Ablationpt_PT
dc.subjectCetuximabpt_PT
dc.subjectDisease Progressionpt_PT
dc.subjectDisease-Free Survivalpt_PT
dc.subjectFemalept_PT
dc.subjectHepatectomypt_PT
dc.subjectHumanspt_PT
dc.subjectLiver Neoplasmspt_PT
dc.subjectLymphatic Metastasispt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectPostoperative Carept_PT
dc.subjectPreoperative Carept_PT
dc.subjectProspective Studiespt_PT
dc.subjectRegistriespt_PT
dc.subjectColonic Neoplasmspt_PT
dc.subjectRectal Neoplasmspt_PT
dc.subjectCHLC CHBPTpt_PT
dc.titleResection of Colorectal Liver Metastases After Second-Line Chemotherapy: Is It Worthwhile? A LiverMetSurvey Analysis of 6415 Patientspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage15pt_PT
oaire.citation.startPage7pt_PT
oaire.citation.titleEuropean Journal of Cancerpt_PT
oaire.citation.volume78pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Eur J Cancer 2017 7.pdf
Size:
716.84 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CHBPT - Artigos