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Association Between Glycated Albumin, Fructosamine, and HbA1c with Neonatal Outcomes in a Prospective Cohort of Women with Gestational Diabetes Mellitus

2019Journal article Open access
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dc.contributor.authorMendes, N
dc.contributor.authorAlves, M
dc.contributor.authorAndrade, R
dc.contributor.authorRibeiro, R
dc.contributor.authorPapoila, AL
dc.contributor.authorSerrano, F
dc.date.accessioned2023-02-20T15:51:19Z
dc.date.available2023-02-20T15:51:19Z
dc.date.issued2019
dc.description.abstractObjective: To investigate whether glycated albumin, fructosamine, and hemoglobin A1c (HbA1c) are associated with neonatal complications in newborns of pregnant women with gestational diabetes mellitus (GDM). Methods: Between November 2016 and September 2017, women with a singleton pregnancy and GDM were enrolled in a prospective study in an obstetric Portuguese referral center. Glycemic markers were compared between mothers of newborns with and without complications. Multivariable logistic regression models and corresponding areas under the receiver operating characteristic curve (AUC) were used. Results: A total of 85 women participated in the study. Raised levels of glycated albumin and fructosamine were associated with at least one neonatal complication (OR- [odds ratio] estimate: 1.33, P=0.015; OR: 1.24, P=0.027, respectively) and with respiratory disorders at birth (OR 1.41, P=0.004; OR 1.26, P=0.014, respectively). HbA1c was not associated with these outcomes. All biomarkers were associated with large-for-gestational age (LGA) status (OR 1.61, P<0.001; OR 1.45, P<0.001; OR 3.62, P=0.032 for glycated albumin, fructosamine, and HbA1c, respectively). All had similar AUC for at least one neonatal complication (0.82; 0.81; 0.79, respectively). For newborn respiratory disorders, AUCs were 0.83, 0.81, and 0.76, respectively, and for LGA status were 0.81, 0.79, and 0.71, respectively. Conclusion: Raised values of glycated albumin and fructosamine were associated with particular perinatal complications in newborns of mothers with GDM, better discriminating mothers of newborns with and without complications than HbA1c.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Gynaecol Obstet . 2019 Sep;146(3):326-332.pt_PT
dc.identifier.doi10.1002/ijgo.12897pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4416
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectMAC MED MAFpt_PT
dc.subjectCHLC CINVpt_PT
dc.subjectAdultpt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectBiomarkers / metabolismpt_PT
dc.subjectBlood Glucose / metabolismpt_PT
dc.subjectCase-Control Studiespt_PT
dc.subjectCohort Studiespt_PT
dc.subjectDiabetes, Gestational / physiopathology*pt_PT
dc.subjectFetal Macrosomia / etiologypt_PT
dc.subjectFructosamine / metabolism*pt_PT
dc.subjectGlycated Hemoglobin / metabolism*pt_PT
dc.subjectGlycated Serum Albuminpt_PT
dc.subjectGlycation End Products, Advancedpt_PT
dc.subjectInfant, Newbornpt_PT
dc.subjectInfant, Newborn, Diseases / etiology*pt_PT
dc.subjectLogistic Modelspt_PT
dc.subjectPregnancypt_PT
dc.subjectProspective Studiespt_PT
dc.subjectROC Curvept_PT
dc.subjectSerum Albumin / metabolism*pt_PT
dc.titleAssociation Between Glycated Albumin, Fructosamine, and HbA1c with Neonatal Outcomes in a Prospective Cohort of Women with Gestational Diabetes Mellituspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage332pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage326pt_PT
oaire.citation.titleInternational Journal of Gynecology & Obstetricspt_PT
oaire.citation.volume146pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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