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New Perspectives on the Conservative Management of Osteoradionecrosis of the Mandible: a Literature Review

2016-11Journal article Open access
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dc.contributor.authorAlpuim Costa, D
dc.contributor.authorPorfírio Costa, T
dc.contributor.authorNetto, E
dc.contributor.authorJoaquim, N
dc.contributor.authorVentura, I
dc.contributor.authorPratas, AC
dc.contributor.authorWinckler, P
dc.contributor.authorPires Silva, I
dc.contributor.authorPinho, AC
dc.contributor.authorGoulão Sargento, I
dc.contributor.authorGamito Guerreiro, F
dc.contributor.authorMoreira, A
dc.date.accessioned2024-06-26T14:15:03Z
dc.date.available2024-06-26T14:15:03Z
dc.date.issued2016-11
dc.description.abstractOver the last decades, several therapeutic options were considered in the treatment of the osteoradionecrosis (ORN) of the mandible, including supportive measures, ultrasound therapy, corticosteroids, hyperbaric oxygen, surgical resection with reconstruction, and, more recently, drugs capable of reversing the fibroatrophic process. Once established, the ORN does not spontaneously disappear and a standard treatment has not yet been defined. The clear clinical effectiveness of hyperbaric oxygen therapy (HBOT) varies according to the literature and there are some economic/logistic issues to be considered; the triplet tocopherol/pentoxifylline/clodronate demands greater evidence from randomized clinical trials and also resilience from the patient, given the long treatment duration and its possible side effects. Controversy around the ideal treatment of the initial stage ORN of the mandible persists. More rigorous randomized prospective trials are essential. The purpose of this article was to review the relevant literature on the physiopathology of ORN of the mandible and discuss the new perspectives of its conservative treatment. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1708-1716, 2016.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationHead Neck . 2016 Nov;38(11):1708-1716.pt_PT
dc.identifier.doi10.1002/hed.24495pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4938
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectHSJ CIR MAXFACpt_PT
dc.subjectHSJ CIRpt_PT
dc.subjectHumanspt_PT
dc.subjectAntioxidants / therapeutic usept_PT
dc.subjectBone Density Conservation Agents / therapeutic usept_PT
dc.subjectClodronic Acid / therapeutic usept_PT
dc.subjectConservative Treatmentpt_PT
dc.subjectDrug Therapy, Combinationpt_PT
dc.subjectHyperbaric Oxygenation*pt_PT
dc.subjectMandibular Diseases / therapy*pt_PT
dc.subjectOsteoradionecrosis / drug therapypt_PT
dc.subjectOsteoradionecrosis / physiopathologypt_PT
dc.subjectOsteoradionecrosis / therapy*pt_PT
dc.subjectPentoxifylline / therapeutic usept_PT
dc.subjectTocopherols / therapeutic usept_PT
dc.titleNew Perspectives on the Conservative Management of Osteoradionecrosis of the Mandible: a Literature Reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1716pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage1708pt_PT
oaire.citation.titleHead & Neckpt_PT
oaire.citation.volume38pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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