Repository logo
 
Publication

Recurrence After Operative Management of Intrahepatic Cholangiocarcinoma

2013Journal article Open access
Simple item page
dc.contributor.authorHyder, O
dc.contributor.authorHatzaras, I
dc.contributor.authorSotiropoulos, G
dc.contributor.authorPaul, A
dc.contributor.authorAlexandrescu, S
dc.contributor.authorMarques, H
dc.contributor.authorPulitano, C
dc.contributor.authorBarroso, E
dc.contributor.authorClary, B
dc.contributor.authorAldrighetti, L
dc.contributor.authorFerrone, C
dc.contributor.authorZhu, A
dc.contributor.authorBauer, T
dc.contributor.authorWalters, D
dc.contributor.authorGroeschl, R
dc.contributor.authorGamblin, C
dc.contributor.authorMarsh, J
dc.contributor.authorNguyen, K
dc.contributor.authorTurley, R
dc.contributor.authorPopescu, I
dc.contributor.authorHubert, C
dc.contributor.authorMeyer, S
dc.contributor.authorChoti, M
dc.contributor.authorGigot, JF
dc.contributor.authorMentha, G
dc.contributor.authorPawlik, T
dc.date.accessioned2013-06-12T10:48:50Z
dc.date.available2013-06-12T10:48:50Z
dc.date.issued2013
dc.description.abstractINTRODUCTION: Data on recurrence after operation for intrahepatic cholangiocarcinoma (ICC) are limited. We sought to investigate rates and patterns of recurrence in patients after operative intervention for ICC. METHODS: We identified 301 patients who underwent operation for ICC between 1990 and 2011 from an international, multi-institutional database. Clinicopathologic data, recurrence patterns, and recurrence-free survival (RFS) were analyzed. RESULTS: During the median follow up duration of 31 months (range 1-208), 53.5% developed a recurrence. Median RFS was 20.2 months and 5-year actuarial disease-free survival, 32.1%. The most common site for initial recurrence after operation of ICC was intrahepatic (n = 98; 60.9%), followed by simultaneous intra- and extrahepatic disease (n = 30; 18.6%); 33 (21.0%) patients developed extrahepatic recurrence only as the first site of recurrence. Macrovascular invasion (hazard ratio [HR], 2.08; 95% confidence interval [CI], 1.34-3.21; P < .001), nodal metastasis (HR, 1.55; 95% CI, 1.01-2.45; P = .04), unknown nodal status (HR, 1.57; 95% CI, 1.10-2.25; P = .04), and tumor size ≥5 cm (HR, 1.84; 95% CI, 1.28-2.65; P < .001) were independently associated with increased risk of recurrence. Patients were assigned a clinical score from 0 to 3 according to the presence of these risk factors. The 5-year RFS for patients with scores of 0, 1, 2, and 3 was 61.8%, 36.2%, 19.5%, and 9.6%, respectively. CONCLUSION: Recurrence after operative intervention for ICC was common. Disease recurred both at intra- and extrahepatic sites with roughly the same frequency. Factors such as lymph node metastasis, tumor size, and vascular invasion predict highest risk of recurrence.por
dc.identifier.citationSurgery. 2013 Jun;153(6):811-8por
dc.identifier.urihttp://hdl.handle.net/10400.17/1291
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.subjectColangiocarcinomapor
dc.subjectNeoplasias das Vias Biliarespor
dc.subjectVias Biliares Intra-Hepáticas
dc.subjectSobrevivência Livre de Doença
dc.subjectEstimativa de Kaplan-Meier
dc.subjectNeoplasias Hepáticas
dc.subjectMetástases Linfáticas
dc.subjectInvasão Neoplásica
dc.subjectFactores de Risco
dc.subjectRecidiva Neoplásica Local
dc.titleRecurrence After Operative Management of Intrahepatic Cholangiocarcinomapor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage818por
oaire.citation.startPage811por
oaire.citation.titleSurgerypor
rcaap.rightsopenAccesspor
rcaap.typearticlepor

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Surgery 2013 811.pdf
Size:
609.09 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CIR - Artigos