Publication
Epidemiology of Acute Liver Failure from a Regional Liver Transplant Center in Portugal
| dc.contributor.author | Simões, C | |
| dc.contributor.author | Santos, S | |
| dc.contributor.author | Vicente, M | |
| dc.contributor.author | Cardoso, FS | |
| dc.date.accessioned | 2019-12-09T16:33:36Z | |
| dc.date.available | 2019-12-09T16:33:36Z | |
| dc.date.issued | 2018-12 | |
| dc.description.abstract | Background and Aims: Acute liver failure (ALF) is a rare disease with potentially high mortality rates. We aimed to study the recent epidemiology of ALF in one of the Portuguese liver transplant (LT) regions. Methods: We assessed a retrospective cohort including 34 consecutive patients with ALF admitted to the intensive care unit (ICU) of Curry Cabral Hospital (Lisbon, Portugal) between October 2013 and December 2016. Results: The median age (IQR) was 49 (31-67) years, and 21 (62%) of the cohort were female. Non-paracetamol etiologies were found in 29 patients (85%). On ICU admission, grade 3-4 hepatic encephalopathy developed in 10 patients (29%); invasive mechanical ventilation, vasopressors, and renal replacement therapy were required for 8 (24%), 7 (21%), and 5 (15%) of the patients, respectively; the King's College criteria (KCC) were fulfilled by 16 patients (47%). Of the 15 (44%) nontransplanted patients, 11 (73%) died during their hospital stay. Of the 19 (56%) transplanted patients, 4 (21%) died during their hospital stay. KCC were not associated with hospital mortality (p = 0.97), but they were significantly associated with LT (p = 0.008). Conclusions: In a Portuguese cohort of patients with ALF, non-paracetamol etiologies were predominant. Hospital mortality was much lower amongst transplanted patients. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | GE Port J Gastroenterol. 2018 Dec;26(1):33-39. | pt_PT |
| dc.identifier.doi | 10.1159/000487312 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.17/3386 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Sociedade Portuguesa de Gastrenterologia | pt_PT |
| dc.subject | CHLC GAS | pt_PT |
| dc.subject | CHLC MED | pt_PT |
| dc.subject | HCC UCI | pt_PT |
| dc.subject | Liver Failure | pt_PT |
| dc.subject | Etiology | pt_PT |
| dc.subject | Transplantation | pt_PT |
| dc.title | Epidemiology of Acute Liver Failure from a Regional Liver Transplant Center in Portugal | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 39 | pt_PT |
| oaire.citation.issue | 1 | pt_PT |
| oaire.citation.startPage | 33 | pt_PT |
| oaire.citation.title | GE Portuguese Journal of Gastroenterology | pt_PT |
| oaire.citation.volume | 26 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |