Acute Kidney Injury in the Context of Inflammatory Bowel Disease - A Clinical Case

Extraintestinal manifestations of inflammatory bowel disease are common and extendable to all organs. Kidney and lower genitourinary system occurs in 4-23% of cases. This may be dependent on inflammatory bowel disease activity, secondary to metabolic disorders, drugs or others. We present a case of a 68-year-old man with ulcerative colitis for 22 years admitted in our department for acute nephritic syndrome. Urinary microscopy suggested glomerular injury. A kidney biopsy was performed and was compatible with acute interstitial nephritis and IgA nephropathy. Toxicity of mesalazine and glomerulonephritis secondary to ulcerative colitis were assumed. The patient suspended mesalazine and started prednisolone with clinical improvement. Our purpose is to sensitize the importance of having a prompt and thorough evaluation of acute kidney injury in patients with inflammatory bowel disease. We briefly review the broad spectrum of kidney manifestations in this population, focusing on mesalazine-induced nephrotoxicity.

Keywords

Inflammatory bowel disease kidney injury/acute IgA nephropathy Tubulointerstitial nephritis Mesalazine HCC PAT CLIN HCC NEF

URI

http://hdl.handle.net/10400.17/4360

Citation

Clin Nephrol Ren Care 2021, 7:065

Publisher

ClinMed International Library

Collections

PAT CLIN - Artigos
NEF - Artigos

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