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Association Between Alcohol Intake and Cardiac Remodeling

2018Journal article Open access
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dc.contributor.authorRodrigues, P
dc.contributor.authorSantos-Ribeiro, S
dc.contributor.authorTeodoro, T
dc.contributor.authorVeloso Gomes, F
dc.contributor.authorLeal, I
dc.contributor.authorReis, JP
dc.contributor.authorGoff, DC
dc.contributor.authorGonçalves, A
dc.contributor.authorLima, J
dc.date.accessioned2020-08-13T15:04:02Z
dc.date.available2020-08-13T15:04:02Z
dc.date.issued2018
dc.description.abstractBackground: Alcohol-induced cardiotoxicity is incompletely understood. Specifically, the long-term impact of alcohol use on ventricular remodeling or dysfunction, its modulators, and effect thresholds among young adults remain controversial. Objectives: The authors sought to evaluate a potential relationship between alcohol intake and cardiac remodeling, assessed by echocardiography, over 20 years of follow-up. Methods: Among the CARDIA (Coronary Artery Risk Development in Young Adults) study cohort, the authors studied all subjects without baseline heart disorders who provided adequate information on their drinking habits and underwent echocardiographic evaluation at years 5 and 25 of the study. The echocardiographic outcomes were left ventricular (LV) ejection fraction, indexed LV end-diastolic volume and LV mass, and left atrial diameter. Participants were grouped according to their weighted-average weekly drinking habits. An additional analysis used the estimated cumulative alcohol consumption. Regression models and multivariable fractional polynomials were used to evaluate the association between alcohol consumption and the outcomes. Results: Among the 2,368 participants, alcohol consumption was an independent predictor of higher indexed LV mass (p = 0.014) and indexed LV end-diastolic volume (p = 0.037), regardless of sex. No significant relationship between alcohol intake and LV ejection fraction was found. Drinking predominantly wine was associated with less cardiac remodeling and there was a nonsignificant trend for a harmful effect of binge drinking. Conclusions: After 20 years of follow-up, alcohol intake was associated with adverse cardiac remodeling, although it was not related with LV systolic dysfunction in this initially healthy young cohort. Our results also suggest that drinking predominantly wine associates with less deleterious findings in cardiac structure.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Am Coll Cardiol. 2018 Sep 25;72(13):1452-1462.pt_PT
dc.identifier.doi10.1016/j.jacc.2018.07.050pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3497
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectAlcohol Drinkingpt_PT
dc.subjectBinge Drinkingpt_PT
dc.subjectCohort Studiespt_PT
dc.subjectDiastolept_PT
dc.subjectFemalept_PT
dc.subjectFollow-Up Studiespt_PT
dc.subjectHeart Ventriclespt_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectStroke Volumept_PT
dc.subjectVentricular Remodelingpt_PT
dc.subjectEchocardiographypt_PT
dc.subjectHCC IMApt_PT
dc.titleAssociation Between Alcohol Intake and Cardiac Remodelingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1462pt_PT
oaire.citation.issue13pt_PT
oaire.citation.startPage1452pt_PT
oaire.citation.titleJournal of the American College of Cardiologypt_PT
oaire.citation.volume72pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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