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Cross-Protection to New Drifted Influenza A(H3) Viruses and Prevalence of Protective Antibodies to Seasonal Influenza, During 2014 in Portugal

2017Journal article Open access
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dc.contributor.authorGuiomar, R
dc.contributor.authorPereira da Silva, S
dc.contributor.authorConde, P
dc.contributor.authorCristóvão, P
dc.contributor.authorMaia, AC
dc.contributor.authorPechirra, P
dc.contributor.authorRodrigues, AP
dc.contributor.authorNunes, B
dc.contributor.authorMilho, L
dc.contributor.authorCoelho, AP
dc.contributor.authorFernandes, A
dc.contributor.authorCaseiro, P
dc.contributor.authorRodrigues, F
dc.contributor.authorCorreia, L
dc.contributor.authorPereira-Vaz, J
dc.contributor.authorAlmeida, S
dc.contributor.authorBranquinho, P
dc.contributor.authorCôrte-Real, R
dc.contributor.authorViseu, R
dc.contributor.authorPeres, MJ
dc.contributor.authorSanches, R
dc.contributor.authorDantas, F
dc.contributor.authorFreitas, L
dc.contributor.authorAndrade, G
dc.contributor.authorMaurílio, M
dc.contributor.authorCaldeira, F
dc.contributor.authorCabral Veloso, R
dc.contributor.authorMota-Vieira, L
dc.contributor.authorSoares, M
dc.contributor.authorCouto, AR
dc.contributor.authorBruges-Armas, J
dc.contributor.authorMouro Pinto, R
dc.contributor.authorSobrinho Simões, J
dc.contributor.authorCosta, MR
dc.contributor.authorGuimarães, JT
dc.contributor.authorMartins, L
dc.contributor.authorCunha, M
dc.date.accessioned2019-11-12T16:11:52Z
dc.date.available2019-11-12T16:11:52Z
dc.date.issued2017
dc.description.abstractINTRODUCTION: Immune profile for influenza viruses is highly changeable over time. Serological studies can assess the prevalence of influenza, estimate the risk of infection, highlight asymptomatic infection rate and can also provide data on vaccine coverage. The aims of the study were to evaluate pre-existing cross-protection against influenza A(H3) drift viruses and to assess influenza immunity in the Portuguese population. MATERIALS AND METHODS: We developed a cross-sectional study based on a convenience sample of 626 sera collected during June 2014, covering all age groups, both gender and all administrative health regions of Portugal. Sera antibody titers for seasonal and new A(H3) drift influenza virus were evaluated by hemagglutination inhibition assay (HI). Seroprevalence to each seasonal influenza vaccine strain virus and to the new A(H3) drift circulating strain was estimated by age group, gender and region and compared with seasonal influenza-like illness (ILI) incidence rates before and after the study period. RESULTS: Our findings suggest that seroprevalences of influenza A(H3) (39.9%; 95% CI: 36.2-43.8) and A(H1)pdm09 (29.7%; 95% CI: 26.3-33.4) antibodies were higher than for influenza B, in line with high ILI incidence rates for A(H3) followed by A(H1)pdm09, during 2013/2014 season. Low pre-existing cross-protection against new A(H3) drift viruses were observed in A(H3) seropositive individuals (46%). Both against influenza A(H1)pdm09 and A(H3) seroprotection was highest in younger than 14-years old. Protective antibodies against influenza B were highest in those older than 65years old, especially for B/Yamagata lineage, 33.3% (95% CI: 25.7-41.9). Women showed a high seroprevalence to influenza, although without statistical significance, when compared to men. A significant decreasing trend in seroprotection from north to south regions of Portugal mainland was observed. CONCLUSIONS: Our results emphasize that low seroprotection increases the risk of influenza infection in the following winter season. Seroepidemiological studies can inform policy makers on the need for vaccination and additional preventive measures.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVaccine. 2017 Apr 11;35(16):2092-2099.pt_PT
dc.identifier.doi10.1016/j.vaccine.2017.02.019pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3358
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectAdolescentpt_PT
dc.subjectAdultpt_PT
dc.subjectAgedpt_PT
dc.subjectAged, 80 and overpt_PT
dc.subjectAntibodies, Viralpt_PT
dc.subjectChildpt_PT
dc.subjectChild, Preschoolpt_PT
dc.subjectCross-Sectional Studiespt_PT
dc.subjectFemalept_PT
dc.subjectHemagglutination Inhibition Testspt_PT
dc.subjectHumanspt_PT
dc.subjectIncidencept_PT
dc.subjectInfantpt_PT
dc.subjectInfant, Newbornpt_PT
dc.subjectInfluenza A viruspt_PT
dc.subjectInfluenza, Humanpt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectPortugalpt_PT
dc.subjectSeroepidemiologic Studiespt_PT
dc.subjectYoung Adultpt_PT
dc.subjectCross Protectionpt_PT
dc.subjectCHLC PAT CLINpt_PT
dc.titleCross-Protection to New Drifted Influenza A(H3) Viruses and Prevalence of Protective Antibodies to Seasonal Influenza, During 2014 in Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2099pt_PT
oaire.citation.issue16pt_PT
oaire.citation.startPage2092pt_PT
oaire.citation.titleVaccinept_PT
oaire.citation.volume35pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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