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Association Between Memory B-Cells and Clinical and Immunological Features of Primary Sjögren’s Syndrome and Sicca Patients

2018-06Journal article Open access
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dc.contributor.authorBarcelos, F
dc.contributor.authorMartins, C
dc.contributor.authorPapoila, A
dc.contributor.authorGeraldes, C
dc.contributor.authorCardigos, J
dc.contributor.authorNunes, G
dc.contributor.authorLopes, T
dc.contributor.authorAlves, N
dc.contributor.authorVaz-Patto, J
dc.contributor.authorBranco, J
dc.contributor.authorBorrego, LM
dc.date.accessioned2023-03-01T12:43:00Z
dc.date.available2023-03-01T12:43:00Z
dc.date.issued2018-06
dc.description.abstractB-cells play a pivotal role in primary Sjögren's syndrome (pSS) pathogenesis. We aim to (1) evaluate the distribution of B-lymphocyte subpopulations in pSS and Sicca patients, (2) establish cut-off points that discriminate pSS from controls, (3) evaluate the association between memory B-cells and phenotypic features in pSS. We included 57 pSS patients, 68 Sicca and 24 healthy controls. Circulating B-cells were characterized by flow cytometry as naïve and memory subsets and classified from Bm1 to Bm5. Compared to controls, pSS patients had lower percentages (29.5 vs 44.4%) and absolute numbers (47 vs 106 cells/µl) of memory B-cells. Through ROC curves, a cut-off of ≤ 58 total memory B-cells/µl yielded a specificity of 0.88 and a sensitivity of 0.60 for pSS, and was met by 59.6% of pSS patients, 38.8% of Sicca and 12.5% of controls. A cut-off of < 23.5 Switched-memory B-cells/µl yielded a specificity of 0.88 and a sensitivity of 0.54 and was met by 54.4% of pSS patients, 37.3% of Sicca and 12.5% of controls. In pSS, lower total memory B-cells count was associated with longer disease duration (14.3 vs 8.1 years, p = 0.006) and more active disease profile, as evaluated by the European League Against Rheumatism (EULAR) Sjögren's Syndrome Disease Activity Index (ESSDAI) (3.1 vs 1.4, p = 0.043). Decreased numbers of memory B-cells clearly discriminated pSS from controls and can also have prognostic value. It remains to be clarified whether Sicca patients with decreased memory B-cells represent pSS and if B-cell profiling could help in the diagnosis of pSS.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRheumatol Int . 2018 Jun;38(6):1063-1073.pt_PT
dc.identifier.doi10.1007/s00296-018-4018-0pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4430
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.subjectHSAC OFTpt_PT
dc.subjectAdultpt_PT
dc.subjectHumanspt_PT
dc.subjectFemalept_PT
dc.subjectB-Lymphocytes / cytology*pt_PT
dc.subjectB-Lymphocytes / immunologypt_PT
dc.subjectCase-Control Studiespt_PT
dc.subjectDiagnosis, Differentialpt_PT
dc.subjectPrognosispt_PT
dc.subjectROC Curvept_PT
dc.subjectSjogren's Syndrome / diagnosispt_PT
dc.subjectSjogren's Syndrome / immunology*pt_PT
dc.titleAssociation Between Memory B-Cells and Clinical and Immunological Features of Primary Sjögren’s Syndrome and Sicca Patientspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1073pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage1063pt_PT
oaire.citation.titleRheumatology Internationalpt_PT
oaire.citation.volume38pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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