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Association of Diabetic Ketoacidosis and HbA1c at Onset with Year-Three HbA1c in Children and Adolescents with Type 1 Diabetes: Data from the International SWEET Registry

2020Journal article Open access
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dc.contributor.authorPiccini, B
dc.contributor.authorSchwandt, A
dc.contributor.authorJefferies, C
dc.contributor.authorKordonouri, O
dc.contributor.authorLimbert, C
dc.contributor.authorArslanoglu, I
dc.contributor.authorCardona-Hernandez, R
dc.contributor.authorCoutant, R
dc.contributor.authorKim, JH
dc.contributor.authorPreiksa, RT
dc.contributor.authorPundziute Lyckå, A
dc.contributor.authorRami-Merhar, B
dc.contributor.authorRichmond, E
dc.contributor.authorSavova, R
dc.contributor.authorTodorovic, S
dc.contributor.authorVeeze, HJ
dc.contributor.authorToni, S
dc.date.accessioned2021-04-30T14:12:19Z
dc.date.available2021-04-30T14:12:19Z
dc.date.issued2020
dc.description.abstractObjective: To establish whether diabetic ketoacidosis (DKA) or HbA1c at onset is associated with year-three HbA1c in children with type 1 diabetes (T1D). Methods: Children with T1D from the SWEET registry, diagnosed <18 years, with documented clinical presentation, HbA1c at onset and follow-up were included. Participants were categorized according to T1D onset: (a) DKA (DKA with coma, DKA without coma, no DKA); (b) HbA1c at onset (low [<10%], medium [10 to <12%], high [≥12%]). To adjust for demographics, linear regression was applied with interaction terms for DKA and HbA1c at onset groups (adjusted means with 95% CI). Association between year-three HbA1c and both HbA1c and presentation at onset was analyzed (Vuong test). Results: Among 1420 children (54% males; median age at onset 9.1 years [Q1;Q3: 5.8;12.2]), 6% of children experienced DKA with coma, 37% DKA without coma, and 57% no DKA. Year-three HbA1c was lower in the low compared to high HbA1c at onset group, both in the DKA without coma (7.1% [6.8;7.4] vs 7.6% [7.5;7.8], P = .03) and in the no DKA group (7.4% [7.2;7.5] vs 7.8% [7.6;7.9], P = .01), without differences between low and medium HbA1c at onset groups. Year-three HbA1c did not differ among HbA1c at onset groups in the DKA with coma group. HbA1c at onset as an explanatory variable was more closely associated with year-three HbA1c compared to presentation at onset groups (P = .02). Conclusions: Year-three HbA1c is more closely related to HbA1c than to DKA at onset; earlier hyperglycemia detection might be crucial to improving year-three HbA1c.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPediatr Diabetes . 2020 Mar;21(2):339-348pt_PT
dc.identifier.doi10.1111/pedi.12946pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3679
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectChildpt_PT
dc.subjectComapt_PT
dc.subjectDiabetes Mellitus, Type 1pt_PT
dc.subjectDiabetic Ketoacidosispt_PT
dc.subjectFemalept_PT
dc.subjectGlycated Hemoglobin Apt_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectRegistriespt_PT
dc.subjectHDE END PEDpt_PT
dc.titleAssociation of Diabetic Ketoacidosis and HbA1c at Onset with Year-Three HbA1c in Children and Adolescents with Type 1 Diabetes: Data from the International SWEET Registrypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage348pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage339pt_PT
oaire.citation.titlePediatric diabetespt_PT
oaire.citation.volume21pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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