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Composite Outcomes in Observational Studies of Ulcerative Colitis: a Systematic Review and Meta‐Analysis

2021-02Journal article Open access
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dc.contributor.authorMagro, F
dc.contributor.authorAlves, C
dc.contributor.authorSantiago, M
dc.contributor.authorMinistro, P
dc.contributor.authorLago, P
dc.contributor.authorCorreia, L
dc.contributor.authorGonçalves, R
dc.contributor.authorCarvalho, D
dc.contributor.authorPortela, F
dc.contributor.authorDias, C
dc.contributor.authorDignass, A
dc.contributor.authorDanese, S
dc.contributor.authorPeyrin‐Biroulet, L
dc.contributor.authorEstevinho, MM
dc.contributor.authorMoreira, P
dc.date.accessioned2023-08-02T14:11:52Z
dc.date.available2023-08-02T14:11:52Z
dc.date.issued2021-02
dc.description.abstractBackground: Ulcerative colitis (UC) has been the focus of numerous observational studies over the years and a common strategy employed in their design is the use of composite and aggregate outcomes. Objective: This systematic review and meta-analysis aims to identify composite and aggregate outcomes of observational studies in UC and to evaluate how the number and type of variables included and the length of follow-up affect the frequency of patients that achieve these outcomes. Methods: A systematic literature search was carried out using MEDLINE [via PubMed], Scopus, and Web of Science online databases. Observational studies that included UC patients and reported composite or aggregate outcomes were identified. A set of variables considered to be representative of progressive or disabling UC was defined, the proportion of patients attaining the outcomes was determined and a random-effects meta-analysis was performed by dividing the identified studies into subgroups according to different criteria of interest. Results: A total of 10,264 records were identified in the systematic search, of which 33 were retained for qualitative analysis and 20 were included in the meta-analysis. The mean frequency for composite outcomes was 0.363 [95% confidence interval (CI) 0.323-0.403]. The frequency of composite outcome for the subgroup of studies that included the variable "Biologics" was significantly higher than for those in which this variable was not reported [0.410; 95% CI 0.364-0.457 versus 0.298; 95% CI 0.232-0.364; p = 0.006]. Composite outcomes were also more frequent as the follow-up duration increased. Conclusion: The frequency of composite outcomes in observational studies of UC is dependent on the specific identity of the variables being reported. Moreover, longer follow-up periods are associated with higher frequencies of composite outcomes. The evidence provided here is useful for the design of future observational studies of UC that aim to maximize the frequency of patients that achieve composite outcomes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationUnited European Gastroenterol J . 2022 Feb;10(1):54-72.pt_PT
dc.identifier.doi10.1002/ueg2.12183pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4622
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectHSAC GASpt_PT
dc.subjectBiaspt_PT
dc.subjectAdultpt_PT
dc.subjectHumanspt_PT
dc.subjectChildpt_PT
dc.subjectBiological Products / therapeutic usept_PT
dc.subjectColitis, Ulcerative / diagnosispt_PT
dc.subjectColitis, Ulcerative / surgerypt_PT
dc.subjectColitis, Ulcerative / therapy*pt_PT
dc.subjectConfidence Intervalspt_PT
dc.subjectDisease Progressionpt_PT
dc.subjectFollow-Up Studiespt_PT
dc.subjectHospitalizationpt_PT
dc.subjectImmunosuppressive Agents / therapeutic usept_PT
dc.subjectObservational Studies as Topic* / methodspt_PT
dc.subjectSteroids / therapeutic usept_PT
dc.subjectTime Factorspt_PT
dc.subjectTreatment Outcomept_PT
dc.titleComposite Outcomes in Observational Studies of Ulcerative Colitis: a Systematic Review and Meta‐Analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage72pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage54pt_PT
oaire.citation.titleUnited European Gastroenterology Journalpt_PT
oaire.citation.volume10pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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