Publication
Personality, Brain Asymmetry, and Neuroendocrine Reactivity in Two Immune-Mediated Disorders: a Preliminary Report
| dc.contributor.author | Martin Martins, J | |
| dc.contributor.author | Alves, J | |
| dc.contributor.author | Trinca, A | |
| dc.contributor.author | Grima, B | |
| dc.contributor.author | Vale, S | |
| dc.contributor.author | Vasconcelos, T | |
| dc.contributor.author | Riso, N | |
| dc.contributor.author | Vaz Riscado, M | |
| dc.contributor.author | Charneco da Costa, J | |
| dc.date.accessioned | 2014-05-08T11:51:12Z | |
| dc.date.available | 2014-05-08T11:51:12Z | |
| dc.date.issued | 2002 | |
| dc.description.abstract | Development of some immune-mediated disorders may depend on dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. To explore neuropsychologic mechanisms in relation to the abnormal endocrine reactivity in patients with systemic lupus erythematosus (SLE) and chronic hepatitis C (CHC) we used the corticotropin releasing hormone (CRH) test, the Minnesota Multiphasic Personality Inventory (MMPI), and the Edinburgh Inventory of Manual Preference Inventory (EIMP). Compared to controls, the adrenocorticotrophic hormone (ACTH) response to CRH was reduced in CHC, while SLE presented reduced baseline dehydroepiandrosterone sulfate levels; higher neurotic scores were found in SLE and higher behavior deviant scores in CHC. Peak ACTH levels were a significant factor for the MMPI profile variability, while the manual preference score was a significant factor for the ACTH response. Personality and manual preference contribute to neuroendocrine abnormalities. Different behavioral and neuroimmunoendocrine models emerge for these disorders. | por |
| dc.identifier.citation | Brain Behav Immun. 2002 Aug;16(4):383-97 | por |
| dc.identifier.uri | http://hdl.handle.net/10400.17/1797 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Elsevier | por |
| dc.subject | HCC END | por |
| dc.subject | Hormona Adrenocorticotrópica | por |
| dc.subject | Sulfato de Desidroepiandrosterona | por |
| dc.subject | Lateralidade Funcional | por |
| dc.subject | Cérebro | por |
| dc.subject | Hepatite C | por |
| dc.subject | Hidrocortisona | por |
| dc.subject | Lúpus Eritematoso Sistémico | por |
| dc.subject | MMPI | por |
| dc.subject | Sistemas Neurossecretores | por |
| dc.subject | Personalidade | por |
| dc.subject | Projectos Piloto | por |
| dc.subject | Prolactina | por |
| dc.title | Personality, Brain Asymmetry, and Neuroendocrine Reactivity in Two Immune-Mediated Disorders: a Preliminary Report | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 397 | por |
| oaire.citation.startPage | 383 | por |
| oaire.citation.title | Brain, Behavior, and Immunity | por |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |