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The Role of Ophthalmic Imaging in Central Nervous System Degeneration in Systemic Lupus Erythematosus

2018-06Journal article Open access
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dc.contributor.authorDias-Santos, A
dc.contributor.authorProença, R
dc.contributor.authorTavares Ferreira, J
dc.contributor.authorPinheiro, S
dc.contributor.authorCunha, JP
dc.contributor.authorProença, R
dc.contributor.authorMoraes-Fontes, MF
dc.date.accessioned2018-08-28T11:12:05Z
dc.date.available2018-08-28T11:12:05Z
dc.date.issued2018-06
dc.description.abstractSystemic lupus erythematosus (SLE) is an autoimmune connective tissue disorder that can involve any organ system. Central nervous system involvement can be a severe life threatening complication, ultimately resulting in severe neurodegenerative changes. Magnetic resonance imaging suggests that neurodegeneration, which may have deleterious effects on brain function, may occur early in SLE and experimental models suggest that neuroprotection may be feasible and beneficial. The retina is an extension of the brain. Recent ophthalmic imaging technologies are capable of identifying early changes in retinal and choroidal morphology and circulation that may reflect CNS degeneration. However, their utility in monitoring CNS involvement in SLE has been poorly studied as these have only been performed in small cohorts, in a cross-sectional design, non-quantitatively and without correlation to disease activity. The authors aim to review the current understanding of neurodegeneration associated with SLE, with particular focus on the visual pathway. We describe the neuropathology of the visual system in SLE and the evidence for retinal and choroidal neurodegenerative and microvascular changes using optical coherence tomography technology. We aim to describe the potential role of optical imaging modalities in NPSLE diagnosis and their likely impact on the study of neuronal function.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAutoimmun Rev. 2018 Jun;17(6):617-624pt_PT
dc.identifier.doi10.1016/j.autrev.2018.01.011pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3043
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectBrainpt_PT
dc.subjectCross-Sectional Studiespt_PT
dc.subjectEyept_PT
dc.subjectHumanspt_PT
dc.subjectLupus Erythematosus, Systemicpt_PT
dc.subjectLupus Vasculitis, Central Nervous Systempt_PT
dc.subjectMagnetic Resonance Imagingpt_PT
dc.subjectNerve Degenerationpt_PT
dc.subjectDiagnostic Techniques, Ophthalmologicalpt_PT
dc.subjectHSAC OFTpt_PT
dc.subjectHSAC DAUTOIMpt_PT
dc.subjectHCC DAUTOIMpt_PT
dc.titleThe Role of Ophthalmic Imaging in Central Nervous System Degeneration in Systemic Lupus Erythematosuspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage624pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage617pt_PT
oaire.citation.volume17pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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