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Ki-67 Proliferation Index in Gastric Cancer - Biologic Significance

2016-06Other Open access
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dc.contributor.authorNabais, C
dc.contributor.authorCaldeira Fradique, A
dc.contributor.authorOliveira, M
dc.contributor.authorQuaresma, L
dc.contributor.authorGualdino Silva, J
dc.contributor.authorVasconcelos, V
dc.contributor.authorSacadura, J
dc.contributor.authorCosta, L
dc.contributor.authorCabrita, F
dc.contributor.authorMateus Marques, R
dc.contributor.authorEsteves, J
dc.contributor.authorFernandez, G
dc.contributor.authorGuedes da Silva
dc.date.accessioned2016-07-04T14:46:32Z
dc.date.available2016-07-04T14:46:32Z
dc.date.issued2016-06
dc.description.abstractObjectives/Introdution: Ki-67 protein has been used as an indicator of proliferation activity in tumor cells. In gastric cancer the prognostic value has not been fully understood. This study was designed to assess the biologic significance of Ki-67 proliferation index (PI) in gastric cancer. Material/Methods: Seventy-two patients with gastric cancer were evaluated. These patients underwent gastric resection, and the tumor tissue was stained immunohistochemically. Ki-67 PI was defined as the percentage of tumor cells positive for Ki-67. Ki-67 PI was correlated with clinicopathological characteristics and patient survival. Results: A low Ki-67 PI (less than or equal to 50%) was associated with poorly differentiated histology - diffuse type (p=0.009) and signet ring cells (p=0.004) - and younger age (p=0.022). A worse prognosis in patients with low Ki-67 PI was also found (a mean survival of 41.8 vs 63 months for high Ki-67 PI group), but not statistically significant (p=0.623, log rank test). Discussion/Conclusion: We found an inversely correlation between Ki-67 PI and histological differentiation grade. Patients in group with low Ki-67 PI are younger, with poorly differentiated histology and have a lower mean survival. Like other studies already suggested, we may have two different tumors phenotypes - highly invasive with low proliferative capability, and less invasive potential with higher proliferative ability. However, in this sample, no significant prognostic value was achieved between both.pt_PT
dc.identifier.citationIN: Esophageal and Gastric Cancer Initiative; 2016, 16 a 18 Junho. Lisboa, Portugal.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/2535
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherUnidade Funcional de Patologia Esofago-Gástricapt_PT
dc.subjectHSJ CIRpt_PT
dc.subjectStomach Neoplasmspt_PT
dc.subjectKi-67 Antigenpt_PT
dc.titleKi-67 Proliferation Index in Gastric Cancer - Biologic Significancept_PT
dc.typeother
dspace.entity.typePublication
oaire.citation.conferencePlaceLisboapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typeotherpt_PT

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