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Pregnancy Outcomes in Portuguese Women with Multiple Sclerosis: The PREGNIMS Study

2019-02Journal article Open access
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dc.contributor.authorNovo, Ana
dc.contributor.authorCastelo, Juliana
dc.contributor.authorde Sousa, Ary
dc.contributor.authorAmorim, Isabe
dc.contributor.authorAlves, José Nuno
dc.contributor.authorCalejo, Margarida
dc.contributor.authorMonteiro, Ana
dc.contributor.authorArenga, Marta
dc.contributor.authorShamasna, Motasem
dc.contributor.authorVale, José
dc.contributor.authorSá, Maria José
dc.contributor.authorPalavra, Filipe
dc.date.accessioned2019-08-02T15:10:03Z
dc.date.available2019-08-02T15:10:03Z
dc.date.issued2019-02
dc.description.abstractINTRODUCTION: Several questions about pregnancy in women with multiple sclerosis (MS) have been discussed, but clarification is still needed in some very practical issues. Portuguese data on this subject remain scattered and need to be analyzed in order to standardize clinical practice. OBJECTIVE: This study aimed to describe and analyze the impact of MS on pregnancy and perinatal health of children born to Portuguese mothers with the disease. MATERIAL AND METHODS: This is a multicenter, retrospective study of a cohort of Portuguese women with MS who were pregnant and who gave birth between 01/01/2011 and 31/12/2015. Demographic and clinical data related to maternal disease, pregnancy progression and events, childbirth and newborn health were collected. RESULTS: Ninety-seven women were recruited and 90 live births were evaluated. The mean maternal age at conception was 32.5 years, and 63.9% had no relapses in the previous year (98.0% had a relapsing-remitting MS and the EDSS score was ≤ 3 in 92.8% of the cases). Only 50.5% of the women had a preconception specific evaluation and 60 children were exposed to immunomodulatory therapies during pregnancy. Nineteen women had relapses during pregnancy. Childbirth was induced in 22.7% of the cases, and the caesarean section rate was 34%. Children exposed to immunomodulatory drugs during pregnancy had a lower birth length (p = 0.014), and there was also a trend toward lower birth weight (p = 0.054) in these newborns. Pre-conception EDSS score negatively correlated with the duration of pregnancy (r = -0.22; p = 0.029), weight (r = -0.23; p = 0.031) and cephalic perimeter at birth (r = -0.24; p = 0.033). There was no relationship between the occurrence of relapses or progression in EDSS score during pregnancy with any variables related to the newborn. CONCLUSIONS: In our cohort, it has been confirmed that MS has no negative effect on pregnancy or on children's perinatal health. However, the use of immunomodulatory drugs may have some impact on newborns' somatometric features.pt_PT
dc.description.versioninfo:eu-repo/semantics/submittedVersionpt_PT
dc.identifier.citationMult Scler Relat Disord. 2019 Feb;28:172-176.pt_PT
dc.identifier.doi10.1016/j.msard.2018.12.033pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3277
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectAdolescentpt_PT
dc.subjectAdultpt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectImmunologic Factorspt_PT
dc.subjectInfant, Newbornpt_PT
dc.subjectMultiple Sclerosispt_PT
dc.subjectPortugalpt_PT
dc.subjectPregnancypt_PT
dc.subjectPregnancy Complicationspt_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectYoung Adultpt_PT
dc.subjectPregnancy Outcomept_PT
dc.subjectCHLC NEUpt_PT
dc.titlePregnancy Outcomes in Portuguese Women with Multiple Sclerosis: The PREGNIMS Studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage176pt_PT
oaire.citation.startPage172pt_PT
oaire.citation.titleMultiple Sclerosis and Related Disorderspt_PT
oaire.citation.volume28pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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