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Preoperative Abnormalities in Serum Sodium Concentrations Are Associated with Higher in-Hospital Mortality in Patients Undergoing Major Surgery

2016-01Journal article Open access
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dc.contributor.authorCecconi, M
dc.contributor.authorHochrieser, H
dc.contributor.authorChew, M
dc.contributor.authorGrocott, M
dc.contributor.authorHoeft, A
dc.contributor.authorHoste, A
dc.contributor.authorJammer, I
dc.contributor.authorPosch, M
dc.contributor.authorMetnitz, P
dc.contributor.authorPelosi, P
dc.contributor.authorMoreno, R
dc.contributor.authorPearse, RM
dc.contributor.authorVincent, JL
dc.contributor.authorRhodes, A
dc.date.accessioned2017-07-20T14:55:23Z
dc.date.available2017-07-20T14:55:23Z
dc.date.issued2016-01
dc.description.abstractBACKGROUND: Abnormal serum sodium concentrations are common in patients presenting for surgery. It remains unclear whether these abnormalities are independent risk factors for postoperative mortality. METHODS: This is a secondary analysis of the European Surgical Outcome Study (EuSOS) that provided data describing 46 539 patients undergoing inpatient non-cardiac surgery. Patients were included in this study if they had a recorded value of preoperative serum sodium within the 28 days immediately before surgery. Data describing preoperative risk factors and serum sodium concentrations were analysed to investigate the relationship with in-hospital mortality using univariate and multivariate logistic regression techniques. RESULTS: Of 35 816 (77.0%) patients from the EuSOS database, 21 943 (61.3%) had normal values of serum sodium (138-142 mmol litre(-1)) before surgery, 8538 (23.8%) had hyponatraemia (serum sodium ≤137 mmol litre(-1)) and 5335 (14.9%) had hypernatraemia (serum sodium ≥143 mmol litre(-1)). After adjustment for potential confounding factors, moderate to severe hypernatraemia (serum sodium concentration ≥150 mmol litre(-1)) was independently associated with mortality [odds ratio 3.4 (95% confidence interval 2.0-6.0), P<0.0001]. Hyponatraemia was not associated with mortality. CONCLUSIONS: Preoperative abnormalities in serum sodium concentrations are common, and hypernatraemia is associated with increased mortality after surgery. Abnormalities of serum sodium concentration may be an important biomarker of perioperative risk resulting from co-morbid disease.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBr J Anaesth. 2016 Jan;116(1):63-9pt_PT
dc.identifier.doi10.1093/bja/aev373pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/2728
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Presspt_PT
dc.subjectAgedpt_PT
dc.subjectComorbiditypt_PT
dc.subjectEuropept_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectHypernatremiapt_PT
dc.subjectHyponatremiapt_PT
dc.subjectIntensive Care Unitspt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectOdds Ratiopt_PT
dc.subjectPostoperative Complicationspt_PT
dc.subjectProspective Studiespt_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectRisk Factorspt_PT
dc.subjectSodiumpt_PT
dc.subjectSurgical Procedures, Operativept_PT
dc.subjectHospital Mortalitypt_PT
dc.subjectPreoperative Periodpt_PT
dc.subjectHSJ UCIpt_PT
dc.titlePreoperative Abnormalities in Serum Sodium Concentrations Are Associated with Higher in-Hospital Mortality in Patients Undergoing Major Surgerypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage69pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage63pt_PT
oaire.citation.titleBritish Journal of Anaesthesiapt_PT
oaire.citation.volume116pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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