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Gla-Rich Protein Is a Novel Vitamin K-Dependent Protein Present in Serum that Accumulates at Sites of Pathological Calcifications

2009-12Journal article Open access
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dc.contributor.authorViegas, C
dc.contributor.authorCavaco, S
dc.contributor.authorNeves, P
dc.contributor.authorFerreira, A
dc.contributor.authorJoão, A
dc.contributor.authorWilliamson, M
dc.contributor.authorPrice, P
dc.contributor.authorCancela, ML
dc.contributor.authorSimes, D
dc.date.accessioned2021-11-24T15:38:04Z
dc.date.available2021-11-24T15:38:04Z
dc.date.issued2009-12
dc.description.abstractMineralization of soft tissues is an abnormal process that occurs in any body tissue and can greatly increase morbidity and mortality. Vitamin K-dependent (VKD) proteins play a crucial role in these processes; matrix Gla protein is considered one of the most relevant physiological inhibitors of soft tissue calcification know to date. Several studies have suggested that other, still unknown, VKD proteins might also be involved in soft tissue calcification pathologies. We have recently identified in sturgeon a new VKD protein, Gla-rich protein (GRP), which contains the highest ratio between number of Gla residues and size of the mature protein so far identified. Although mainly expressed in cartilaginous tissues of sturgeon, in rat GRP is present in both cartilage and bone. We now show that GRP is a circulating protein that is also expressed and accumulated in soft tissues of rats and humans, including the skin and vascular system in which, when affected by pathological calcifications, GRP accumulates at high levels at sites of mineral deposition, indicating an association with calcification processes. The high number of Gla residues and consequent mineral binding affinity properties strongly suggest that GRP may directly influence mineral formation, thereby playing a role in processes involving connective tissue mineralization.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAm J Pathol. 2009 Dec;175(6):2288-98.pt_PT
dc.identifier.doi10.2353/ajpath.2009.090474.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3921
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectHSAC DERpt_PT
dc.subjectAnimalspt_PT
dc.subjectHumanspt_PT
dc.subjectRatspt_PT
dc.subjectBlood Vessels / metabolismpt_PT
dc.subjectBlotting, Westernpt_PT
dc.subjectCalcinosis / metabolism*pt_PT
dc.subjectElectrophoresis, Polyacrylamide Gelpt_PT
dc.subjectGene Expressionpt_PT
dc.subjectIn Situ Hybridizationpt_PT
dc.subjectOsteocalcin / biosynthesis*pt_PT
dc.subjectOsteocalcin / bloodpt_PT
dc.subjectReverse Transcriptase Polymerase Chain Reactionpt_PT
dc.subjectSwinept_PT
dc.subjectSkin / metabolismpt_PT
dc.titleGla-Rich Protein Is a Novel Vitamin K-Dependent Protein Present in Serum that Accumulates at Sites of Pathological Calcificationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2289pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage2288pt_PT
oaire.citation.titleAmerican Journal of Pathologypt_PT
oaire.citation.volume175pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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