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Alzheimer's Disease: a Review of its Visual System Neuropathology. Optical Coherence Tomography-a Potential Role As a Study Tool in Vivo

2016-11Journal article Open access
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dc.contributor.authorCunha, JP
dc.contributor.authorMoura-Coelho, N
dc.contributor.authorProença, R
dc.contributor.authorDias-Santos, A
dc.contributor.authorFerreira, J
dc.contributor.authorLouro, C
dc.contributor.authorCastanheira-Dinis, A
dc.date.accessioned2017-09-15T14:31:08Z
dc.date.available2017-09-15T14:31:08Z
dc.date.issued2016-11
dc.description.abstractAlzheimer's disease (AD) is a prevalent, long-term progressive degenerative disorder with great social impact. It is currently thought that, in addition to neurodegeneration, vascular changes also play a role in the pathophysiology of the disease. Visual symptoms are frequent and are an early clinical manifestation; a number of psychophysiologic changes occur in visual function, including visual field defects, abnormal contrast sensitivity, abnormalities in color vision, depth perception deficits, and motion detection abnormalities. These visual changes were initially believed to be solely due to neurodegeneration in the posterior visual pathway. However, evidence from pathology studies in both animal models of AD and humans has demonstrated that neurodegeneration also takes place in the anterior visual pathway, with involvement of the retinal ganglion cells' (RGCs) dendrites, somata, and axons in the optic nerve. These studies additionally showed that patients with AD have changes in retinal and choroidal microvasculature. Pathology findings have been corroborated in in-vivo assessment of the retina and optic nerve head (ONH), as well as the retinal and choroidal vasculature. Optical coherence tomography (OCT) in particular has shown great utility in the assessment of these changes, and it may become a useful tool for early detection and monitoring disease progression in AD. The authors make a review of the current understanding of retinal and choroidal pathological changes in patients with AD, with particular focus on in-vivo evidence of retinal and choroidal neurodegenerative and microvascular changes using OCT technology.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGraefes Arch Clin Exp Ophthalmol. 2016 Nov;254(11):2079-2092pt_PT
dc.identifier.doi10.1007/s00417-016-3430-ypt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/2746
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.subjectCHLC OFTpt_PT
dc.subjectAlzheimer Disease/complicationspt_PT
dc.subjectChoroid/pathologypt_PT
dc.subjectChoroid Diseases/diagnosispt_PT
dc.subjectChoroid Diseases/etiologypt_PT
dc.subjectOptic Disk/pathology
dc.subjectRetinal Diseases/diagnosis
dc.subjectRetinal Diseases/etiology
dc.subjectRetinal Ganglion Cells/pathology
dc.subjectTomography, Optical Coherence/methods
dc.titleAlzheimer's Disease: a Review of its Visual System Neuropathology. Optical Coherence Tomography-a Potential Role As a Study Tool in Vivopt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2092pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage2079pt_PT
oaire.citation.titleGraefe's Archive for Clinical and Experimental Ophthalmologypt_PT
oaire.citation.volume254pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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