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Disease Activity Assessment of Rheumatic Diseases During Pregnancy: a Comprehensive Review of Indices Used in Clinical Studies

2019-02Journal article Open access
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dc.contributor.authorAndreoli, L
dc.contributor.authorGerardi, MC
dc.contributor.authorFernandes, M
dc.contributor.authorBortoluzzi, A
dc.contributor.authorBellando-Randone, S
dc.contributor.authorBrucato, A
dc.contributor.authorCaporali, R
dc.contributor.authorChighizola, C
dc.contributor.authorChimenti, MS
dc.contributor.authorConigliaro, P
dc.contributor.authorCutolo, M
dc.contributor.authorCutro, MS
dc.contributor.authorD'Angelo, S
dc.contributor.authorDoria, A
dc.contributor.authorElefante, E
dc.contributor.authorFredi, M
dc.contributor.authorGaleazzi, M
dc.contributor.authorGerosa, M
dc.contributor.authorGovoni, M
dc.contributor.authorIuliano, A
dc.contributor.authorLarosa, M
dc.contributor.authorLazzaroni, MG
dc.contributor.authorMatucci-Cerinic, M
dc.contributor.authorMeroni, M
dc.contributor.authorMeroni, P
dc.contributor.authorMosca, M
dc.contributor.authorPatanè, M
dc.contributor.authorPazzola, G
dc.contributor.authorPendolino, M
dc.contributor.authorPerricone, R
dc.contributor.authorRamoni, V
dc.contributor.authorSalvarani, C
dc.contributor.authorSebastiani, G
dc.contributor.authorSelmi, C
dc.contributor.authorSpinelli, F
dc.contributor.authorValesini, G
dc.contributor.authorScirè, CA
dc.contributor.authorTincani, A
dc.date.accessioned2021-04-20T16:00:01Z
dc.date.available2021-04-20T16:00:01Z
dc.date.issued2019-02
dc.description.abstractPregnancy requires a special management in women with inflammatory rheumatic diseases (RDs), with the aim of controlling maternal disease activity and avoiding fetal complications. Despite the heterogeneous course of RDs during pregnancy, their impact on pregnancy largely relates to the extent of active inflammation at the time of conception. Therefore, accurate evaluation of disease activity is crucial for the best management of pregnant patients. Nevertheless, there are limitations in using conventional measures of disease activity in pregnancy, as some items included in these instruments can be biased by symptoms or by physiological changes related to pregnancy and the pregnancy itself may influence laboratory parameters used to assess disease activity. This article aims to summarize the current literature about the available instruments to measure disease activity during pregnancy in RDs. Systemic lupus erythematosus is the only disease with instruments that have been modified to account for several adaptations which might interfere with the attribution of signs or symptoms to disease activity during pregnancy. No modified-pregnancy indices exist for women affected by other RDs, but standard indices have been applied to pregnant patients. The current body of knowledge shows that the physiologic changes that occur during pregnancy need to be either adapted from existing instruments or developed to improve the management of pregnant women with RDs. Standardized instruments to assess disease activity during pregnancy would be helpful not only for clinical practice but also for research purposes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAutoimmun Rev. 2019 Feb;18(2):164-176.pt_PT
dc.identifier.doi10.1016/j.autrev.2018.08.008pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3665
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectPregnancypt_PT
dc.subjectPregnancy Complicationspt_PT
dc.subjectRheumatic Diseasespt_PT
dc.subjectHCC MEDpt_PT
dc.titleDisease Activity Assessment of Rheumatic Diseases During Pregnancy: a Comprehensive Review of Indices Used in Clinical Studiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage176pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage164pt_PT
oaire.citation.titleAutoimmunity Reviewspt_PT
oaire.citation.volume18pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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