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Secretory IgA and T Cells Targeting SARS-CoV-2 Spike Protein Are Transferred to the Breastmilk Upon mRNA Vaccination

2021Journal article Open access
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dc.contributor.authorGonçalves, J
dc.contributor.authorJuliano, AM
dc.contributor.authorCharepe, N
dc.contributor.authorAlenquer, M
dc.contributor.authorAthayde, D
dc.contributor.authorFerreira, F
dc.contributor.authorArcher, M
dc.contributor.authorAmorim, MJ
dc.contributor.authorSerrano, F
dc.contributor.authorSoares, H
dc.date.accessioned2022-01-21T15:09:44Z
dc.date.available2022-01-21T15:09:44Z
dc.date.issued2021
dc.description.abstractIn view of the scarcity of data to guide decision making, we evaluated how BNT162b2 and mRNA-1273 vaccines affect the immune response in lactating women and the protective profile of breastmilk. Compared with controls, lactating women had a higher frequency of circulating RBD memory B cells and higher anti-RBD antibody titers but similar neutralizing capacity. We show that upon vaccination, immune transfer to breastmilk occurs through a combination of anti-spike secretory IgA (SIgA) antibodies and spike-reactive T cells. Although we found that the concentration of anti-spike IgA in breastmilk might not be sufficient to directly neutralize SARS-CoV-2, our data suggest that cumulative transfer of IgA might provide the infant with effective neutralization capacity. Our findings put forward the possibility that breastmilk might convey both immediate (through anti-spike SIgA) and long-lived (via spike-reactive T cells) immune protection to the infant. Further studies are needed to address this possibility and to determine the functional profile of spike T cells.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCell Rep Med. 2021 Dec 21;2(12):100468.pt_PT
dc.identifier.doi10.1016/j.xcrm.2021.100468pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3960
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectMAC MED MAFpt_PT
dc.subjectAntibodies, Viral / bloodpt_PT
dc.subjectAntibodies, Viral / immunologypt_PT
dc.subjectCOVID-19 / immunologypt_PT
dc.subjectCOVID-19 / prevention & controlpt_PT
dc.subjectCOVID-19 Vaccines / immunology*pt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectImmunity, Maternally-Acquiredpt_PT
dc.subjectImmunoglobulin A, Secretory / immunology*pt_PT
dc.subjectLactation / immunologypt_PT
dc.subjectMemory B Cells / immunologypt_PT
dc.subjectMilk, Human / immunology*pt_PT
dc.subjectSARS-CoV-2 / immunology*pt_PT
dc.subjectSpike Glycoprotein, Coronavirus / immunology*pt_PT
dc.subjectT-Lymphocytes / immunology*pt_PT
dc.subjectmRNA Vaccines / immunologypt_PT
dc.subjectVaccinationpt_PT
dc.titleSecretory IgA and T Cells Targeting SARS-CoV-2 Spike Protein Are Transferred to the Breastmilk Upon mRNA Vaccinationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage100468pt_PT
oaire.citation.titleCell Reports. Medicinept_PT
oaire.citation.volume2pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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