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Outcomes of Parenchyma-Preserving Hepatectomy and Right Hepatectomy for Solitary Small Colorectal Liver Metastasis: A LiverMetSurvey Study

2017Journal article Open access
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dc.contributor.authorHosokawa, I
dc.contributor.authorAllard, MA
dc.contributor.authorMirza, DF
dc.contributor.authorKaiser, G
dc.contributor.authorBarroso, E
dc.contributor.authorLapointe, R
dc.contributor.authorLaurent, C
dc.contributor.authorFerrero, A
dc.contributor.authorMiyazaki, M
dc.contributor.authorAdam, R
dc.date.accessioned2019-03-20T16:42:33Z
dc.date.available2019-03-20T16:42:33Z
dc.date.issued2017
dc.description.abstractBACKGROUND: Occasionally, right hepatectomy, rather than parenchyma-preserving hepatectomy, has been performed for solitary small colorectal liver metastasis. The relative oncologic benefits of parenchyma-preserving hepatectomy and right hepatectomy are unclear. This study compared the outcomes of patients with solitary small colorectal liver metastasis in the right liver who underwent parenchyma-preserving hepatectomy and those who underwent right hepatectomy. METHODS: The study population consisted of a multicentric cohort of 21,072 patients operated for colorectal liver metastasis between 2000 and 2015 whose data were collected in the LiverMetSurvey registry. Patients with a pathologically confirmed solitary tumor of less than 30 mm in size in the right liver were included. The short- and long-term outcomes of patients who underwent parenchyma-preserving hepatectomy were compared to those of patients who underwent right hepatectomy. RESULTS: Of the 1,720 patients who were eligible for the study, 1,478 (86%) underwent parenchyma-preserving hepatectomy and 242 (14%) underwent right hepatectomy. The parenchyma-preserving hepatectomy group was associated with lower rates of major complications (3% vs 10%; P < .001) and 90-day mortality (1% vs 3%; P = .008). Liver recurrence occurred similarly in both groups (20% vs 22%; P = .39). The 5-year recurrence-free survival and overall survival rates were similar in both groups. However, in patients with liver-only recurrence, repeat hepatectomy was more frequently performed in the parenchyma-preserving hepatectomy group than in the right hepatectomy group (67% vs 31%; P < .001), and the overall 5-year survival rate was significantly higher in the parenchyma-preserving hepatectomy group than in the right hepatectomy group (55% vs 23%; P < .001). CONCLUSION: Parenchyma-preserving hepatectomy should be considered the standard procedure for solitary small colorectal liver metastasis in the right liver when technically feasible.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSurgery. 2017 Aug;162(2):223-232.pt_PT
dc.identifier.doi10.1016/j.surg.2017.02.012pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3204
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectAgedpt_PT
dc.subjectCohort Studiespt_PT
dc.subjectColorectal Neoplasmspt_PT
dc.subjectDisease-Free Survivalpt_PT
dc.subjectFemalept_PT
dc.subjectHepatectomypt_PT
dc.subjectHumanspt_PT
dc.subjectLiver Neoplasmspt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectNeoplasm Recurrence, Localpt_PT
dc.subjectSurvival Ratept_PT
dc.subjectTreatment Outcomept_PT
dc.subjectHCC CHBPTpt_PT
dc.titleOutcomes of Parenchyma-Preserving Hepatectomy and Right Hepatectomy for Solitary Small Colorectal Liver Metastasis: A LiverMetSurvey Studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage232pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage223pt_PT
oaire.citation.titleSurgerypt_PT
oaire.citation.volume162pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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