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Survival after Resection of Multiple Tumor Foci of Intrahepatic Cholangiocarcinoma

2019Journal article Open access
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dc.contributor.authorBuettner, S
dc.contributor.authorTen Cate, D
dc.contributor.authorBagante, F
dc.contributor.authorAlexandrescu, S
dc.contributor.authorPinto Marques, H
dc.contributor.authorLamelas, J
dc.contributor.authorAldrighetti, L
dc.contributor.authorGamblin, T
dc.contributor.authorMaithel, S
dc.contributor.authorPulitano, C
dc.contributor.authorMargonis, G
dc.contributor.authorWeiss, M
dc.contributor.authorBauer, T
dc.contributor.authorShen, F
dc.contributor.authorPoultsides, G
dc.contributor.authorMarsh, J
dc.contributor.authorIJzermans, J
dc.contributor.authorPawlik, T
dc.contributor.authorKoerkamp, B
dc.date.accessioned2021-04-14T10:39:10Z
dc.date.available2021-04-14T10:39:10Z
dc.date.issued2019
dc.description.abstractBackground: Multiple tumor foci of intrahepatic cholangiocarcinoma (ICC) are often considered a contra-indication for resection. We sought to define long-term outcomes after resection of ICC in patients with multiple foci. Methods: Patients who underwent resection for ICC between 1990 and 2017 were identified from 12 major HPB centers. Outcomes of patients with solitary lesions, multiple lesions (ML), and oligometastases (OM) were compared. OM were defined as extrahepatic metastases spread to a single organ. Results: One thousand thirteen patients underwent resection of ICC. On final pathology, 185 patients (18.4%) had ML and 27 (2.7%) had OM. Median survival of patients with a solitary tumor was 43.2 months, while the median survival of patients with 2 tumors was 21.2 months; the median survival of patients with 3 or more tumors was 15.3 months (p < 0.001). Five-year survival was 43.3%, 28.0%, and 8.6%, respectively. The median survival of patients without OM was 37.8 months versus 14.9 months among patients with OM (p < 0.001); estimated 5-year survival was 39.3% and 10.6%, respectively. In multivariable analysis, the presence of two lesions was not an independent poor prognostic factor for OS (HR 1.19; 95%CI 0.90-1.57; p = 0.229). However, the presence of three or more tumors was an independent poor prognostic factor for OS (HR 1.97; 95%CI 1.48-2.64; p < 0.001). Conclusion: Resection of multiple liver tumors for patients with ICC did not preclude 5-year survival: in particular, estimated 5-year OS for resection of two tumors was 28.0%.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Gastrointest Surg. 2019 Nov;23(11):2239-2246.pt_PT
dc.identifier.doi10.1007/s11605-019-04184-2pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3643
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.subjectAgedpt_PT
dc.subjectBile Duct Neoplasmspt_PT
dc.subjectBile Ducts, Intrahepaticpt_PT
dc.subjectCholangiocarcinomapt_PT
dc.subjectEuropept_PT
dc.subjectFemalept_PT
dc.subjectHepatectomypt_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectSurvival Ratept_PT
dc.subjectUnited Statespt_PT
dc.subjectHCC CIRpt_PT
dc.titleSurvival after Resection of Multiple Tumor Foci of Intrahepatic Cholangiocarcinomapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2246pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage2239pt_PT
oaire.citation.titleJournal of Gastrointestinal Surgerypt_PT
oaire.citation.volume23pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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