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Differential Expression of Aquaporin-3 and Aquaporin-5 in Pancreatic Ductal Adenocarcinoma

2017Journal article Open access
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dc.contributor.authorDireito, I
dc.contributor.authorPaulino, J
dc.contributor.authorVigia, E
dc.contributor.authorBrito, MA
dc.contributor.authorSoveral, G
dc.date.accessioned2021-08-13T14:12:54Z
dc.date.available2021-08-13T14:12:54Z
dc.date.issued2017
dc.description.abstractBackground and objectives: Aquaporin-5 (AQP5) and -3 (AQP3) are protein channels that showed to be up-regulated in a variety of tumors. Our goal was to investigate the expression pattern of AQP5 and AQP3 in pancreatic ductal adenocarcinomas (PDA) and correlate with cell proliferation, tumor stage and progression, and clinical significance. Methods: 35 PDA samples in different stages of differentiation and locations were analyzed by immunohistochemistry for expression of AQP5, AQP3 and several markers of cell proliferation and tumorigenesis. Results: In PDA samples AQP5 was overexpressed in the apical membrane of intercalated and intralobular ductal cells while AQP3 was expressed at the plasma membrane of ductal cells. AQP5 was also found in infiltrative cancer cells in duodenum. Simultaneous overexpression of EGFR, Ki-67, and CK7, with decreased E-cad and increased Vim that characterize epithelial mesenchymal transition, tumor formation and invasion, strongly suggest AQP3 and AQP5 involvement in cell proliferation and transformation. AQP3 overexpression is reinforced in late and more aggressive PDA stages whereas AQP5 is related with tumor differentiation, suggesting it may represent a novel marker for PDA aggressiveness and intestinal infiltration. Conclusions: These findings suggest AQP3 and AQP5 involvement in PDA development and the usefulness of AQP5 in early PDA diagnosis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Surg Oncol. 2017 Jun;115(8):980-996.pt_PT
dc.identifier.doi10.1002/jso.24605.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3834
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectCHLC CHBPTpt_PT
dc.subjectAdultpt_PT
dc.subjectAgedpt_PT
dc.subjectFemalept_PT
dc.subjectAdenocarcinoma / metabolismpt_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectAquaporin 3 / metabolismpt_PT
dc.subjectAquaporin 5 / metabolismpt_PT
dc.subjectCadherins / metabolismpt_PT
dc.subjectCase-Control Studiespt_PT
dc.subjectErbB Receptors / metabolismpt_PT
dc.subjectKeratins / metabolismpt_PT
dc.subjectKi-67 Antigen / metabolismpt_PT
dc.subjectNeoplasm Proteins / metabolismpt_PT
dc.subjectPancreatic Ducts / metabolismpt_PT
dc.subjectPancreatic Neoplasms / metabolismpt_PT
dc.titleDifferential Expression of Aquaporin-3 and Aquaporin-5 in Pancreatic Ductal Adenocarcinomapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage996pt_PT
oaire.citation.startPage980pt_PT
oaire.citation.titleJournal of Surgical Oncologypt_PT
oaire.citation.volume115pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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